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Bactericidal Activity of Famoxadone Alone and in Mixtures

IP.com Disclosure Number: IPCOM000004594D
Publication Date: 2001-Feb-26
Document File: 4 page(s) / 21K

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Abstract

Bactericidal Activity of Famoxadone Alone and in Mixtures

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Bactericidal Activity of Famoxadone Alone and in Mixtures

Famoxadone (5-methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedione), the compound of Formula I, is described in WO 90/12791, together with its preparation, use as a fungicide and fungicidal compositions containing it. Other methods for the preparation of the compound of Formula I are described in WO 94/11359.

I

The utility of famoxadone alone and in potentially synergistic combinations with other fungicides, insecticides and herbicides for control of a wide range of plant pathogenic fungi has been disclosed previously (Research Disclosure 1996, 388, 489-90). In addition to the control of fungi, this publication also disclosed control of two plant pathogenic bacteria, Xanthomonas campestris pv. vesicatoria and Pseudomonas syringae. Herein we provide data demonstrating the bactericidal activity of famoxadone alone and in combination against Xanthomonas campestris pv. vesicatoria and Pseudomonas syringe pv. tomato, as well as other plant pathogenic bacteria, such as Clavibacter michiganense pv. michiganense and Xanthomonas campestris pv. citri. These data suggest that famoxadone either alone or in mixtures is also likely to control other as yet unexamined plant pathogenic bacteria. Crop protection agents of similar chemical structure and site of action such as fenamidone (Formula II) alone or in combination are also likely to be active against plant pathogenic bacteria.

II

Famoxadone or a composition containing it can be applied by land or aerial application systems, or mixed with soil, peat or other rooting media for the protection of plants against seed-borne, soil-borne or foliar bacterial as well as fungal pathogens.

Test example 1: Xanthomonas campestris pv. vesicatoria in tomatoes.

Applications of fungicide mixtures containing famoxadone and commercial standards were applied to field plots of tomatoes in 2 separate tests. A total of 8-9 applications were made on an 8-12 day spray interval. Levels of naturally occurring bacterial speck caused by Xanthomonas campestris pv. vesicatoria were estimated by visual evaluation of 50 leaves per plot. Data from the two tests were combined.

Table 1. Effects of famoxadone mixtures and competitive standards on bacterial speck (Xanthomonas campestris pv. vesicatoria) in field-grown tomatoes (average over two independent tests).

fungicide

active ingredients

rate,

kg product/ha

infection

occurrence

Equation Pro(r)

22.5% famoxadone+ 30% cymoxanil

0.4

2.1

23

Equation Pro(r)

0.8

1.2

18

Equation Contact(r)

6.25% famoxadone 62.5% mancozeb

0.8

1.8

23

Equation Contact(r)

1.6

1.6

20

Kocide(r)

50% copper hydroxide

2.5

0.9

13

Kocide(r) Dithane M45(r)

50% copper hydroxide 80% mancozeb

1.8 2

1.7

18

untreated

6.9

41

Test example 2: In vitro activity against Xanthomonas campestris pv. citri.

Potato dextrose agar (PDA) was amended with famoxadone mixtures and commercial standards. Plates were inoculated with 100 ┬Ál of inoculum containing 3 x 108 colony forming units/ml Xanthomonas campestris pv. citri, ca...