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Advantageous Fungicidal Compositions

IP.com Disclosure Number: IPCOM000004799D
Publication Date: 2001-Jun-04
Document File: 4 page(s) / 24K

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Abstract

Advantageous Fungicidal Compositions

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Advantageous Fungicidal Compositions

Famoxadone (Formula I), trade name Famoxate(r), also known as 5-methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinone, is a protectant, translaminar and residual fungicide particularly effective against grape downy mildew and potato and tomato late and early blights. Famoxadone inhibits mitochondrial electron transport by blocking the ubiquinol:cytochrome c oxidoreductase site at complex III. Famoxadone is described in WO 90/12791, together with its preparation, use as a fungicide and fungicidal compositions containing it. Other methods for the preparation of famoxadone are described in WO 94/11359.

I

The utility of famoxadone alone and in potentially synergistic combinations with other fungicides, insecticides and herbicides for control of a wide range of plant pathogenic fungi has been disclosed previously (Research Disclosure 1996, 388, 489-90).

Cymoxanil (Formula II), trade name Curzate(r), also known as 2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide, is a commercially available foliar fungicide for control of late blight and downy mildew diseases, particularly for systemic and curative control of potato late blight and grape downy mildew. U.S. Patent 3,954,992 discloses cymoxanil as a fungicide.

II

Advantageous combinations of famoxadone and cymoxanil provide fungicidally active compositions. U.S. Patent 5,948,805 discloses synergistic fungicidal combinations of famoxadone and cymoxanil.

The combination of famoxadone and cymoxanil may also be mixed with additional fungicidal components to provide advantageous fungicidal compositions. By including another fungicide, the resulting multi-component composition can have a broader spectrum of activity, a greater level of intrinsic activity than the individual components alone, or a greater level of activity than the additive control of the individual components of the composition. Combinations with other fungicides having a similar spectrum of disease control but a different mode of action will be particularly advantageous for resistance management.

Example A: Composition

Folpet (Formula III) is an example of an additional fungicidal component. Folpet, also known as 2-[(trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione, is a foliar fungicide for controlling downy mildews such as Plasmopara viticola on grapes by protective action (i.e., no curative activity). Folpet also provides additive control of additional diseases including Botrytis giving an even broader spectrum of agricultural protection.

A composition comprising a mixture of famoxadone, cymoxanil and folpet is recited in Table 1.

Table 1

Formulation Ingredient

Function

famoxadone tech.* (96%ai)

4.2

Compound I

active ingredient

cymoxanil tech.* (96%ai)

8.3

Compound II

active ingredient

folpet tech.* (90%ai)

37.5

Compound III

active ingredient

Borresperse NA

30.0

sodium lignosulfonate

dispersing agent

Supragil WP

5.0

sodium alkylnaphthalene sulfonate

wetting agent

Agrimer 30

5.0

polyvinyl pyrollidone

binder

Fumaric acid

1.0

buff...