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Anti-Epileptogenic Activity of ß-Amino Acids

IP.com Disclosure Number: IPCOM000004829D
Publication Date: 2001-Jun-26
Document File: 1 page(s) / 19K

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Marcus Brady: CONTACT

Related Documents

09/041,371: PATAPP

Abstract

Our novel approach to epilepsy treatment involves preventing the onset of seizures following a brain trauma. Current epilepsy medications target the propogation of hyperexcitability from a seizure focus through the brain. With the described syntheses of substituted ß-amino acids, our target of inhibition of the biochemical pathway that leads to seizure focus development is attained. Molecular designs to face neuromedicinal chemistry challenges such as crossing the Blood-Brain-Barrier, walking the hydrophobicity tightrope, and preventing neurotoxicity will be discussed

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Anti-Epileptogenic Activity of ß-Amino Acids

Angela P. Lyon, Kathryn A. Jones and Donald F. Weaver Department of Chemistry, Queen's University, Kingston, Ontario.

Our novel approach to epilepsy treatment involves preventing the onset of seizures following a brain trauma. Current epilepsy medications target the propogation of hyperexcitability from a seizure focus through the brain. With the described syntheses of substituted ß-amino acids, our target of inhibition of the biochemical pathway that leads to seizure focus development is attained. Molecular designs to face neuromedicinal chemistry challenges such as crossing the Blood-Brain-Barrier, walking the hydrophobicity tightrope, and preventing neurotoxicity will be discussed.