Browse Prior Art Database

Sun Protection Factors and UVA-Parameters of O/W-Sunscreen Emulsions Containing Bis-Ethylhexyloxy Methoxyphenyl Triazine

IP.com Disclosure Number: IPCOM000008768D
Publication Date: 2002-Jul-11
Document File: 13 page(s) / 58K

Publishing Venue

The IP.com Prior Art Database

Abstract

Sunscreen formulations of the o/w-type containing different amounts of the UV-broadband filter Bis-Ethylhexyloxy Methoxyphenyl Triazine (BEMT) alone or in combination with other UVA- or UVB-absorbers have been investigated with respect to the sun protection factor (SPF) and UVA-parameters. The sun protection factors have been measured in vivo following the COLIPA protocol, whereas the UVA-parameters UVA/UVB-ratio and critical wavelength were determined with an in vitro method. According to the filter contents the SPF- and UVA-data varied over a broad range. SPF-data as well as UVA-parameters could be simulated satisfactorily using a calibrated step film model.

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 17% of the total text.

Page 1 of 13

Sun Protection Factors and UVA-Parameters of O/W Sunscreen Emulsions Containing Bis-Ethylhexyloxy Methoxyphenyl Triazine

Bernd Herzog*, Cyrille Deshayes, Katja Quass, Sébastien Mongiat

Ciba Specialty Chemicals Inc., P.O. Box 1266, G-9001.2.28, 79630 Grenzach-Wyhlen, Germany

Abstract

Sunscreen formulations of the o/w-type containing different amounts of the UV- broadband filter Bis-Ethylhexyloxy Methoxyphenyl Triazine (BEMT) alone or in combination with other UVA- or UVB-absorbers have been investigated with respect to the sun protection factor (SPF) and UVA-parameters. The sun protection factors have been measured in vivo following the COLIPA protocol, whereas the UVA- parameters UVA/UVB-ratio and critical wavelength were determined with an in vitro method. According to the filter contents the SPF- and UVA-data varied over a broad range. SPF-data as well as UVA-parameters could be simulated satisfactorily using a calibrated step film model.

* To whom correspondence should be addressed

1

Page 2 of 13

Introduction

The sun protection factor (SPF) is defined as the ratio of the minimal erythemal doses of solar radiation directed to human skin in the presence and in the absence of a sunscreening agent [1]. Based on this definition in vivo methods for sunscreen testing on volunteers have been established [2-4] which are applied when SPF- claims on sunscreen products are made. It has been shown recently that estimation of SPF-values is possible using a calibrated step film model [5]. The present study shows additional data, which support the validity of such calculations. In addition, the step film model is also used for the simulation of the UVA-parameters UVA/UVB-ratio and critical wavelength. All sunscreen formulations referred to contain the UV- broadband filter Bis-Ethylhexyloxy Methoxyphenyl Triazine (BEMT). This filter has been incorporated into o/w-emulsions at different concentrations either alone or combined with one or two further UVA- or UVB-absorbers.

2

Page 3 of 13

Experimental

Chemicals

The UV-absorbers used in this study are listed in the Table 1:

Table 1: UV-Filters Used in this Study

Chemical Name INCI Name Abbreviation Trade Name and Supplier

2-Hydroxy-4-methoxy benzophenone Benzophenone-3 B-3 Uvinul ® M40

(BASF

® T150 (BASF)

Trianilino-(p-carbo-2'-ethylhexyl-1'-oxi)-

1,3,5-triazine Ethylhexyl Triazone EHT Uvinul

  Benzoic acid,4,4'-[[6-[[4-[[(1,1- dimethylethyl)amino]carbonyl]phenyl ]amino]1,3,5-triazine-2,4- diyl]diimino]bis-,bis(2-ethylhexyl)ester

Diethylhexyl Butamido Triazone

DBT Uvasorb ® HEB

(3V Sigma)

MBC Eusolex ® 6300

(Merck)

2-Ethylhexyl p-dimethylaminobenzoate Padimate O Eusolex ® 6007

 1,7,7-Trimethyl-3-(p-methyl phenyl methylene)-bicyclo-[2.2.1]-heptane-2- one

4-Methylbenzylidene Camphor

(Merck)

2-Propenoic acid, 3-(4- methoxyphenyl)-2-ethylhexyl ester Ethylhexyl Methoxycinnamte

EHC Parsol ® MCX

(Roche Vitamins)

4-t-Butyl-4'-methoxydibenzoyl methane Butyl

Methoxydibenzoyl Methane

BMDBM

Parsol ® 1789 (Roche...