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Sodium (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(Nmethyl- N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)- dihydroxy-(E)-6-heptenate Crystal form

IP.com Disclosure Number: IPCOM000019022D
Publication Date: 2003-Aug-27
Document File: 2 page(s) / 103K

Publishing Venue

The IP.com Prior Art Database

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Sodium (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N- methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)- dihydroxy-(E)-6-heptenate Crystal form

                          Sodium (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenate

F

SO2CH3

OH OH

O-Na+

O

Na-Rosu C22H27FN3O6SNa MW=503

N

N CH3

CH3

H3C

N

Two samples of this material were analyzed by X-Ray powder diffraction, and the patterns obtained are shown hereinbelow:

Pattern #1:

The main XRD peaks for pattern #1 are found at 8.5, 8.8, 9.7, 14.5, 18.6, 21.4, 23.4, 25.1,
27.1 and 28.6 degrees two- theta.

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Pattern #2:

The main XRD peaks for pattern #2 are found at 9.5, 15.4, 16.1, 16.8, 18.8, 20.6, 22.6,


23.8, 27.4 and 31.8 degrees two- theta.

X-Ray Powder Diffraction analysis is performed on ARL (Scintag) X-Ray powder

diffractometer model X'TRA, Cu tube, solid state detector. Round standard aluminum sample holders with round zero background quartz plates were used. Scanning parameters: range: 2-40 degrees two-theta, continuous scan, rate 3 deg/min. or 5 deg/min.

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