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tert-butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl- N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)- dihydroxy-(E)-6-heptenate Crystal form

IP.com Disclosure Number: IPCOM000019023D
Publication Date: 2003-Aug-27
Document File: 2 page(s) / 106K

Publishing Venue

The IP.com Prior Art Database

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tert-butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl- N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)- dihydroxy-(E)-6-heptenate

Crystal form

                        tert-butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenate

F

OH OH

C26H36FN3O6S MW=503

N

N CH3

CH3

CO2tBu

H3C

N

SO2CH3

A sample of this material was analyzed by X-Ray powder diffraction, and the pattern obtained is shown hereinbelow:

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The main XRD peaks for tert-butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-6-heptenate are found at


9.8, 12.0, 13.6, 17.2, 18.2, 20.0, 20.9, 22.1, 26.2 degrees two theta.

X-Ray Powder Diffraction analysis is performed on ARL (Scintag) X-Ray powder diffractometer

model X'TRA, Cu-tube, solid state detector. A round standard aluminum sample holder with round zero background quartz plate was used. Scanning parameters: range 2-40 deg.2Θ, continuous scan, rate 3 deg/min.

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