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(+/-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate Intermediates

IP.com Disclosure Number: IPCOM000021213D
Publication Date: 2004-Jan-04
Document File: 3 page(s) / 153K

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(+/-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate Intermediates

2-ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid is used as intermediate in the preparation of (+/-)-1-(cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate.

Different samples of 2-ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid were analyzed by X-Ray Powder diffraction and found to contain different crystal forms α and α-1.

Pattern #1: Main XRD peaks for the pattern 1 are 9.3; 10.1; 11.0; 11.5; 13.4; 19.4; 20.2;

22.1; 23.7; 27.4.

Pattern #2: Main XRD peaks for the pattern 2 are 4.0; 9.5; 9.9; 11.8; 14.6; 16.9; 19.6; 21.0; 21.8; 25.5

1-(Cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate is used as intermediate in the preparation of(+/-)-1-(cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate.

One sample of this material was analyzed by X-Ray powder diffraction, and the pattern obtained is shown here below:

Main XRD peaks for this pattern are 9.2; 10.4; 12.1; 15.2; 17.4; 19.6; 19.9; 21.1; 21.5; 22.2; 22.6

X-Ray Powder Diffractions were performed on ARL (Scintag) X-Ray powder diffractometer model X’TRA, Cu-tube, solid state detect...