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Use of long-chained, defined 2-alkyl branched esters

IP.com Disclosure Number: IPCOM000023775D
Publication Date: 2004-Mar-31
Document File: 15 page(s) / 80K

Publishing Venue

The IP.com Prior Art Database

Related People

Madelein vd Merwe: ATTORNEY [+4]

Related Documents

DE application filed on 2004/03/23: PATAPP

Abstract

This invention relates to the use of known substances as substances active against bacteria, mycota, fungi and viruses. These substances can be used in many different fields, but especially in cosmetic, dermatological or pharmaceutical formulations that contain these substances.

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Use of long-chained, defined branched, 2-alkyl branched acid derivatives as defined and special antimicrobial, antimycotic, antiparasitic, antifungal, antigunge or antiviral active substance.

The healthy human skin is covered by a host of non-pathogenic microorganisms and constitutes an important protection for warding off opportunistic or pathogenic germs. To some extent it has proved useful to enhance this property of the skin by adding biocides (e.g. for deodorants). There are a number of preparations that must be kept in aqueous solutions or dispersions in order to facilitate their production and handling, their transport and storage as well as their use by the end user. In the aqueous medium microorganisms, which are always present as contamination, find optimal living conditions. Due to the great supply of organic and inorganic nutrients and an environmental medium that is favourable as regards temperature and pH-value, an increased and rapid growth of such microorganisms takes place. Together with the increased growth of such microorganisms, among other things, organic substances that are present are decomposed more intensely, which inter alia goes hand in hand with a change in the product-specific properties.

Substances active against bacteria have been known for quite some time, e.g. in the form of antibiotics. Antibiotics are by definition chemical substances that impede the growth of microorganisms. Antibiotics in the present sense are not suitable for medicinal, and especially not for cosmetic uses since during use the metabolic functions of the organism are frequently adversely affected, seeing that an antibiotic acts against all bacteria and cannot be used specially for specific types.

State of the art

There are many different antibacterial substances, based on, for example, long-chained fatty alcohols, such as described in the patent WO 02069706 of SASOL ITALY. There the fatty alcohols with a carbon chain length of 11 atoms are used in a quantity of 0,0005%. Mentioned as examples are 2-ethyl-1-nonanol, 2-propyl-1-octanol or 2-butyl-1-heptanol.

Furthermore there are several patents of the company Beiersdorf, that contain 2-alkyl branched fatty acids as such, as for example the patent DE 19516705 contains the dialkyl-substituted acetic acid of the form

It describes the effect of dialkyl-substituted acetic acid as antimicrobial, antimycotic and antiviral active substances. It was found here that dialkyl-substituted acetic acid prevents the growth of gram-positive and gram-negative bacteria, mycobionts as well as viruses. These compounds have a broad action spectrum. In many fields it is, however, advantageous when this mode of action is limited to, for example, selective microorganisms. Bacteria live on the skin and in the human body itself, even at the rate of approximately ten times more than the cells contained in the body. Hands, hair, mouth and intestine, all internal and external surfaces of the body, are full of such microo...