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Parallel Usage of Contrast Agent for OCT and X-Ray Angiographic Imaging

IP.com Disclosure Number: IPCOM000028075D
Original Publication Date: 2004-May-25
Included in the Prior Art Database: 2004-May-25
Document File: 1 page(s) / 24K

Publishing Venue

Siemens

Related People

Juergen Carstens: CONTACT

Abstract

Optical coherence tomography (OCT) is a new imaging modality using infrared light to perform high resolution imaging of biological tissue. It is used e.g. to visualise the blood vessels in humans and animals. The high resolution of this modality is a big advantage e.g. in visualising vulnerable plaque in coronary arteries. Since OCT cannot "see" through blood, the blood in the imaged vessel needs to be removed temporarily in order to provide a line of sight between the imaging probe and the vessel wall. This can either be done using by a flush medium of saline or by blocking the blood flow via a balloon. For displaying blood vessels in interventional procedures (angiography), a contrast agent is needed. Typically the contrast agent contains iodine. While injecting this contrast agent from the tip of a catheter distally into the vessels, x-ray imaging is turned on. Without the parallel injection of the contrast agent, the blood vessels do not show up on the x-ray image.

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Parallel Usage of Contrast Agent for OCT and X-Ray Angiographic Imaging

Idea: Dr. Reinmar Killmann, DE-Forchheim

Optical coherence tomography (OCT) is a new imaging modality using infrared light to perform high resolution imaging of biological tissue. It is used e.g. to visualise the blood vessels in humans and animals. The high resolution of this modality is a big advantage e.g. in visualising vulnerable plaque in coronary arteries. Since OCT cannot "see" through blood, the blood in the imaged vessel needs to be removed temporarily in order to provide a line of sight between the imaging probe and the vessel wall. This can either be done using by a flush medium of saline or by blocking the blood flow via a balloon.

For displaying blood vessels in interventional procedures (angiography), a contrast agent is needed. Typically the contrast agent contains iodine. While injecting this contrast agent from the tip of a catheter distally into the vessels, x-ray imaging is turned on. Without the parallel injection of the contrast agent, the blood vessels do not show up on the x-ray image.

Since a time-synchronised display of vessel anatomy in x-ray and OCT images has not yet been done, angiographic and OCT measurements are done sequentially. However, the amount of contrast media and saline adds up throughout the procedure and is thus one of the limitations for the usage of OCT and contrast-enhanced x-ray in interventional procedures.

The core of a new idea is to use the contrast agent as a flush medium for OCT. In this case, a trigger unit needs to be added to the interventional lab in order to ensure that the OCT and x-ray imaging systems will deliver images at the right timing relative to the injection of the contrast/flush medium. The usage of an appara...