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1-(((5-Methoxyindol-3-yl)methyliden)amino)-3-pentylguanidin maleate intermediates

IP.com Disclosure Number: IPCOM000028896D
Publication Date: 2004-Jun-07
Document File: 2 page(s) / 109K

Publishing Venue

The IP.com Prior Art Database

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1-(((5-Methoxyindol-3-yl)methyliden)amino)-3-pentylguanidin maleate intermediates 5-MICHO is used as intermediate in the preparation of 1-(((5-Methoxyindol-3- yl)methyliden)amino)-3-pentylguanidin maleate. The chemical name of this compound is: 5-Methoxy-1H-indole-3-carbaldehyde and the CAS number is: 10601- 19-1.

N H

CHO

MeO

C10H9NO2

                         Mol. Wt.: 175.18 Different samples of 5-MICHO were analyzed by X-Ray powder diffraction and found to contain different crystal forms I and II. Form I was purchased from Suzhou Wanqing (supplier: Yann). Form II was purchased from Toppharma (supplier: Toppharma).

Pattern#1: Main XRD peaks for the pattern 1 are 10.1; 14.2; 19.4; 20.1; 20.7; 21.3; 22.5; 26.2;
27.6; 29.9.

14350

CPS

13650

12950

12250

11550

10850

10150

9450

8750

8050

7350

6650

5950

5250

4550

3850

3150

2450

1750

1050

5-MICHO crystal form I

350 5.0

8.0 11.0

14.0

17.0 20.0 23.0 26.0 29.0 32.0

35.0

38.0

Deg.

2.0

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Pattern #2: Main XRD peaks for the pattern 2 are 10.2; 14.3; 17.3; 20.2; 20.8; 22.0; 22.6; 24.8;


27.2; 30.6.

X-Ray Powder Diffraction were performed on ARL (Scintag) X-Ray powder

diffractometer model X'TRA, Cu-tube, solid state detector.A round standard aluminum sample holder with round zero background plate was used. Scanning parameters:2-40 deg.2θ, continuous scan,rate 5deg/min.

53000

CPS

47000

39000

41000

31000

33000

23000

25000

15000

17000

49000

51000

43000

45000

35000

37000

27000

29000

19000

21...