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1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methlypiperazine citrate intermediates

IP.com Disclosure Number: IPCOM000029316D
Publication Date: 2004-Jun-23
Document File: 1 page(s) / 134K

Publishing Venue

The IP.com Prior Art Database

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1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d 5-yl)-4-ethoxyphenyl]sulfonyl]-4-methlypiperazine citrate in

CMP is used as intermediate in the preparation of 1-[[3-(6,7-dihydro-1-methyl-7- oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4- methlypiperazine citrate. The chemical name of this compound is: 1-[[3-(4,7- Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4- ethoxyphenyl]sulfonyl chloride (CMP), and it was purchased from Aryl S.A. Its formula is:

HN

O CH3

3CHOCH3

N

N

Cl

O O

S

N

CMP

                                          Different samples of CMP were analyzed by X-Ray Powder diffraction and found to contain one crystal form α.

Pattern #1: Main XRD peaks for the pattern 1 are: 8.4; 8.6; 12.2; 16.3; 16.7; 21.7; 23.2; 23.5;
23.9; 25.9.

410.88.:tWMol.C 17H19ClN4O4S

X-Ray Powder Diffraction were performed on ARL (Scintag) X-Ray powder

diffractometer model X'TRA, Cu-tube, solid state detector.A round standard aluminum sample holder with round zero background plate was used. Scanning parameters:2-40 deg.2θ, continuous scan,rate 5deg/min.

5375

CPS

5125

4875

4625

4375

4125

3875

3625

3375

3125

2875

2625

2375

2125

1875

1625

1375

1125

875

625

375

CMP crystal form α

2.0

125 5.0

8.0

38.0

Deg.

11.0

14.0

17.0 20.0 23.0 26.0 29.0 32.0 35.0

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