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4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[2'-(1H-tetrazole-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl ester intermediate

IP.com Disclosure Number: IPCOM000030193D
Publication Date: 2004-Aug-01
Document File: 2 page(s) / 96K

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The IP.com Prior Art Database

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  4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[2'-(1H-tetrazole-5-yl) biphenyl-4-ylmethyl]imidazole-5-carboxylic acid 5-methyl-2-oxo-1,3- dioxol-4-ylmethyl ester intermediate

TOLM is used as intermediate in the preparation of 4-(1-Hydroxy-1-methylethyl)-2- propyl-1-[2'-(1H-tetrazole-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid 5- methyl-2-oxo-1,3-dioxol-4-ylmethyl ester. The chemical name of this compound is: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[2'-(trityl-tetrazole-5-yl)biphenyl-4- ylmethyl]imidazole-5-carboxylic acid 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl ester. Its chemical formula is:

TOLM was supplied by Tianyu. Different samples of TOLM were analyzed by X-Ray powder diffraction and found to contain form C, beside the crystalline form B.

Pattern#1: Main XRD peaks for the pattern 2 are: 3.1, 24.1, 10.5, 22.3, 19.3, 21.8, 14.5, 13.3,

Me Me

N

O

OH

C3H7

O

N

O

O

O

N

N

N

N

C(C6H5)3

  C48H44N6O6 MW: 800.6 g/mol


11.1, 25.3, 19.8, 17.3, 21.4 and 18.0 (±0.2 two-theta).

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CPS4920

4680

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3240

3000

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1320

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120

2.0 4.0 6.0 8.0 10.0 12.0 14.0 16.0 18.0 20.0 22.0 24.0 26.0 28.0 30.0 32.0 34.0 36.0 38.0 Deg.

The X-Ray Powder Diffraction were performed an ARL (Scintag) X-Ray powder diffractometer model X'TRA, Cu-tube, solid-state detector. A round standard aluminum holder with round background plate was used. Scanning parameters: 2 - 40 °θ, con...