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Sunscreen formulations containing a 50% dispersion of micronized Trisbiphenyltriazine

IP.com Disclosure Number: IPCOM000033169D
Publication Date: 2004-Nov-30
Document File: 9 page(s) / 35K

Publishing Venue

The IP.com Prior Art Database

Abstract

Disclosed are sunscreen formulations containing a 50% dispersion of micronized trisbiphenyltriazine. As emulsifying system a combination of cetyl phosphate and lecithin is used. With this basic W/O formulation high galenical stability, good spreadability and nice application properties can be created. Sunscreens based on this formulation have a high performance in UV protection and good water resistance.

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Sunscreen formulations containing a 50% dispersion of micronized Trisbiphenyltriazine

Using a combination of cetyl phosphate and lecithin as emulsifying system a basic W/O formulation with high galenical stability, good spreadability and nice application properties can be created. Sunscreens based on this formulation have a high performance in UV protection and good water resistance.

Therefore you incorporate both, cetyl phosphate and lecithine, in a range of 0.1 to 5 % [m/m] of the total formulation. Using components like dimethicone, cetyldimethicone, cyclopenta­siloxane, or isododecane in a concentration range of 0.1 to 5 % besides caprylic/capric tri­gly­ceride, liquid paraffin, dicaprylyl maleate or C12 ‑ C15 alkyl benzoate in the lipid phase good spreadability properties can be reached.

A combination of a 50% dispersion of micronized triazine derivative having the general formula (1)   , wherein

A             is a radical of formula (1a)   ; or (1b)   

R1 and R5 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl;

R2, R3 and R4 independently from each other are hydrogen; or a radical of formula (1c)   , wherein, in formula (1a), at least one of the radicals R2, R3 and R4 are a radical of formula (1c);

R6, R7, R8, R9 and R10 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; ‑COOM; C1-C18-alkylcarboxyl; aminocarbonyl; or mono- or di-C1-C18alkylamino; C1-C10acylamino; ‑COOH;

M            is an alkali metal ion;

x             is 1 or 2; and

y             is a number from 2 to 10;

 (2 ‑ 8 %) with a selection of Tinosorb S (2 ‑ 10 %), Tinosorb M (2 ‑ 8 %), ethylhexyl methoxycinnamate (3 ‑10%), isoamyl methoxycinnamate (3 ‑ 10 %), ethylhexyl triazone (1 ‑ 5 %), octocrylene (1 ‑ 8 %), butyl methoxydibenzoylmethane (0.5 ‑ 5 %), ethylhexyl salicylate (1 ‑ 5 %) and homosalate (1 ‑ 8 %) leads to a high UVB- and UVA-protection.

The compounds of formula (1) are preferably used as UV absorbers in the micro­nized state.

Any known process suitable for the preparation of microparticles can be used for the pre­paration of the micronised UV absorbers, for example wet-milling, wet-kneading, spray-drying from a suitable solvent, by the expansion according to the RESS process (Rapid Expansion of Supercritical Solutions) of supercritical fluids (e.g. CO2) in which the UV filter or filters is/are dissolved, or the expansion of fluid carbon dioxide together with a solution of one or more UV filters in a suitable organic solvent; or by reprecipitation from suitable solvents, including supercritical fluids (GASR process = Gas Anti-Solvent Recrystallisation / PCA process = Precipitation with Compressed Anti-solvents).

For the micronization the compounds of formula (1) are milled together with zir­conium silicate bells (diameter: 0,1 to 4 mm) as grinding aids, a dispersing agent (15 parts of C8‑C16poly­gluco­side or 15 parts C12gy...