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Responsive Centrifugal Blood Chemistry Analysis System

IP.com Disclosure Number: IPCOM000048271D
Original Publication Date: 1982-Jan-01
Included in the Prior Art Database: 2005-Feb-08
Document File: 4 page(s) / 19K

Publishing Venue

IBM

Related People

Curtis, HW: AUTHOR [+4]

Abstract

This article relates generally to centrifugal clinical chemistry analysis systems, and more particularly it relates to a centrifugal blood chemistry analysis system which, during one machine cycle, performs multiple tests on a serum sample from one source and provides realtime optical read-out.

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 32% of the total text.

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Responsive Centrifugal Blood Chemistry Analysis System

This article relates generally to centrifugal clinical chemistry analysis systems, and more particularly it relates to a centrifugal blood chemistry analysis system which, during one machine cycle, performs multiple tests on a serum sample from one source and provides realtime optical read-out.

The present approach automates the performance of blood chemistry by combining a test pack with prepackaged reagents and a centrifuge or rotating platform. By mixing reagents with a biological fluid sample in a controlled temperature environment, desired tests can be carried out in situ and, by providing a cuvette which is integral with the test pack, a sample mixed with desired reagents can be delivered to the cuvette for in-situ optical read-out.

Physical Description:

The present responsive centrifugal analyzer is a systems approach to automating the performance of blood chemistry and immunoassay tests. The system consists of the following components:
1. A specimen identification module capable of optically

reading an identifying label affixed to a patient blood

specimen.
2. A data entry keyboard and display unit for input and

output of data and control information.
3. An automated pipettor-diluter for transfer of specimen

and diluent to a test pack.
4. A number of test packages of reagents, each package

containing the reagents necessary to perform a panel of

tests or an individual test on a single patient specimen.

The test packages are designed for maximum shelf life

and stability and to facilitate the mixing of

or more reagents sequentially with the patient specimen

at timed intervals to perform a variety of tests.
5. An integral refrigerated space to facilitate storage

and efficient dispensing of test packages of reagents

for panels of tests and single tests.
6. A circular specimen-loading station into which patient

specimens and test packages can be placed, and wherein the

specimen and diluent can be automatically transferred

from the specimen test tube to the test packages.
7. An analytical testing module capable of mixing reagents

with diluent and buffers, and subsequently mixing patient

specimens with reagents in a controlled temperature

environment at specifically timed intervals. Such specimens

having been mixed are rotated rapidly to force the mixtures

or specimens and reagents into a cuvette portion of the test

package which can be optically read as to the optical

density over time of the resulting mixture.
8. A series of sensing devices capable of monitoring the

position of the specimens, the test package types being

run, the temperature of the analytical environment, and the

detection of faulty machine operation.

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9. A series of feedback messages informing the operator

of machine status and operation, and a series of alarms to

signal instrument malfunction conditions.
10. A number of microprocessors which facilitate machine

operation and control, and data ma...