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Enhanced UV Sterilization for Sterile Transfer Ports

IP.com Disclosure Number: IPCOM000108287D
Publication Date: 2005-Mar-22
Document File: 1 page(s) / 22K

Publishing Venue

The IP.com Prior Art Database

Abstract

The use one or more photocatalytically activated (PCA) materials such as titanium dioxide or zinc oxide on one or more of the surfaces of the components of a sterile transfer port system can enhance the sterilization effect of the light source. Such materials are well-known, especially in the presence of UV light, to generate free radicals which have an antibacterial effect.

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Enhanced UV Sterilization for Sterile Transfer Ports

Submitter: M. Grzonka/Millipore Corporation,

290 Concord Road

,

Billerica

,

MA

01821

                    Isolators and other sterile suite designs used in the pharmaceutical industry need to have one or more ports or doors that provide access to components into the isolator and egress to finished (typically filled containers) products.

                    Two types are commonly used today, the A/B port and the SAFEPASS™ port available from Millipore Corporation. They both comprise a sealed entryway into an isolator and use either a mating door/container combination (A/B port) or a plastic collar/transfer container (SAFEPASS port). Once mated, the area between them is irradiated with light, such as UV or pulsed light to kill any bacteria that may be present, thus creating a sterile area adjacent the isolator. The isolator door is then opened and access to the container into the isolator occurs. After the container is used, the isolator door is closed and the outer mated component is removed. See US 6,030,578.

                    One potential concern with such systems has been whether all exposed surfaces are adequately treated with light in order to kill all the bacteria. Of particular concern is whether any surface is not directly exposed to the light source and thus potentially not provided with a sufficient level of light to kill the existing bacteria.

 Additionally, to ensure a high level of kill the light is kept on for a duration longer than that otherwise required. This leads...