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Method for Predicting Imaging Equipment, Region of Interests and Measurement Parameters for Follow-up Morphologic Staging of Pathological Findings for Whole Body Examinations (MRI, CT, PET, US etc.)

IP.com Disclosure Number: IPCOM000126880D
Original Publication Date: 2005-Sep-10
Included in the Prior Art Database: 2005-Sep-10
Document File: 5 page(s) / 842K

Publishing Venue

Siemens

Related People

Juergen Carstens: CONTACT

Abstract

With the increasing number of images received as a result of multiple modality whole body examinations (MRI - Magnetic Resonance Imaging, CT - Computed Tomography, PET - Positron Emission Tomography, US - Ultrasound, etc.) makes the evaluation process expensive and time consuming. As proposed in some invention disclosures, the viewing platform and data archiving becomes simple but lacks the possibility to incorporate and compare the follow up studies. The system also lacks the possibility to calculate, learn, train, predict and validate the changes in pathological findings during follow up examinations. In patients with malignant diseases accurate tumor staging is of vast importance as different therapeutic options strongly depend on the tumor stage. Local assessment of tumor size, potential infiltration of adjacent organs, and involvement of regional lymph nodes may be covered by only a limited field-of-view. Determination of distant metastases, however, mandates a whole-body examination. Contrast-enhanced whole-body MRI may be used for whole-body tumor staging, but differentiation of benign from malignant lesions can be problematic due to the lack of functional information. Recently available dual-modality Positron Emission Tomography/Computed Tomography (PET/CT) systems provide accurately fused functional and morphologic data sets and have proven to be of benefit over the two imaging modalities alone. PET/CT, however, mandates the administration of iodine-based contrast agents with an increased allergic potential over gadolinium. Furthermore, PET/CT imaging goes along with a significant radiation exposure.

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Method for Predicting Imaging Equipment, Region of Interests and Measurement Parameters for Follow-up Morphologic Staging of Pathological Findings for Whole Body Examinations (MRI, CT, PET, US etc.)

Idea: Sultan Haider, DE-Erlangen; Dr. Peter Kreisler, DE-Erlangen; Christian Zapf, DE-Erlangen

With the increasing number of images received as a result of multiple modality whole body examinations (MRI - Magnetic Resonance Imaging, CT - Computed Tomography, PET - Positron Emission Tomography, US - Ultrasound, etc.) makes the evaluation process expensive and time consuming. As proposed in some invention disclosures, the viewing platform and data archiving becomes simple but lacks the possibility to incorporate and compare the follow up studies. The system also lacks the possibility to calculate, learn, train, predict and validate the changes in pathological findings during follow up examinations.

In patients with malignant diseases accurate tumor staging is of vast importance as different therapeutic options strongly depend on the tumor stage. Local assessment of tumor size, potential infiltration of adjacent organs, and involvement of regional lymph nodes may be covered by only a limited field-of-view. Determination of distant metastases, however, mandates a whole-body examination. Contrast-enhanced whole-body MRI may be used for whole-body tumor staging, but differentiation of benign from malignant lesions can be problematic due to the lack of functional information. Recently available dual-modality Positron Emission Tomography/Computed Tomography (PET/CT) systems provide accurately fused functional and morphologic data sets and have proven to be of benefit over the two imaging modalities alone. PET/CT, however, mandates the administration of iodine-based contrast agents with an increased allergic potential over gadolinium. Furthermore, PET/CT imaging goes along with a significant radiation exposure.

Until today, the major disadvantage of MRI had been the restricted field of view, whereas skeletal scintigraphy, muscle scintigraphy, and FDG-PET (Fluorodeoxyglucose-Positron Emission Tomography) were staging and screening procedures in clinical routine in the diagnosis of musculo- skeletal diseases. Since the introduction of the table move capabilities and new coil concepts, Whole Body-MRI is feasible for tumor staging and screening patients with skeletal metastases and bone marrow infiltration (example: Whole-body-MRI indicates skip lesions of a PNET-tumor (Primitive Neuroectodermal Tumor), whereas skeletal scintigraphy and FDG-PET failed to detect metastases as shown in figure 1) due to plasmocytoma and muscle inflammation due to polymyositis.

The idea is a method for predicting imaging equipment, region of interests and measurement parameters for follow-up morphologic staging of pathological findings for whole body examinations (MRI, CT, PET, US, etc.). This prediction mechanism predicts the imaging equipment, region of interest an...