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Combinatorial Fabrication and Testing of Porous Media in Capillaries

IP.com Disclosure Number: IPCOM000126946D
Publication Date: 2005-Aug-15
Document File: 1 page(s) / 24K

Publishing Venue

The IP.com Prior Art Database

Abstract

Porous media are combinatorially synthesized within a capillary or the like, by preparing liquid precursors, aspirating them into the capillary, and then subjecting the capillary to processing (e.g. thermal or other methods). The capillary is preferentially readily detachable from the arm of a liquid dispense robot and arrays of capillaries are stored in a rack between fabrication and testing steps. This methodology is particularly suitable for high throughput fabrication and testing of media whose end-use application involves a similar geometry, such as separation and filtration media.

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Combinatorial fabrication and testing of porous media in capillaries.

Porous media are combinatorially synthesized within a capillary or the like, by preparing liquid precursors, aspirating them into the capillary, and then subjecting the capillary to processing (e.g. thermal or other methods). The capillary is preferentially readily detachable from the arm of a liquid dispense robot and arrays of capillaries are stored in a rack between fabrication and testing steps. This methodology is particularly suitable for high throughput fabrication and testing of media whose end-use application involves a similar geometry, such as separation and filtration media.

Millipore manufactures a product called the “Zip Tip”, which is a disposable plastic pipette tip with a filter plug inside the capillary. They manufacture these in-situ, rather than by producing the filters and then loading them into the tips. The process is disclosed in a recently granted patent to Millipore. They also test every tip sold for flow impedance.

The present disclosure differs from the Millipore work in that the Millipore patent describes a specific product and consistent/constant recipe and manufacturing/testing process, whereas this disclosure is a method for high-throughput experimentation in which the composition and processing are intentionally and widely varied.

Polymer precursor solutions are prepared in library format. The polymer composition and molecular weight is varied, as is the solvent mixture. A box of empty pipette tips is provided. A robot picks up one...