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Modeling and Streamlining High-Throughput Screening Data Analysis Process

IP.com Disclosure Number: IPCOM000127329D
Original Publication Date: 2005-Aug-23
Included in the Prior Art Database: 2005-Aug-23
Document File: 3 page(s) / 88K

Publishing Venue

IBM

Abstract

This disclosure provides a new business model to streamline and integrate high-throughput screening data analysis process through using WebSphere Business Integration Modeler to solve a bottleneck problem in life science drug discovery. The new “To-Be” process model can ultimately lead to a cost reduction in terms of time and money for high-throughput screening process.

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Modeling and Streamlining High-Throughput Screening Data Analysis Process

New model to streamline High Throughput Screening Data Analysis (HTSDA) process

The new model for the operation after implementing the proposed solutions for the HTSDA is called "To- Be" model in WebSphere Business Integration Modeler. After modeling and analyzing current processes, "To-Be" solution that streamlines the current processes to solve the bottleneck problem in HTSDA is deduced as shown in Figure 1.

In this redesign of current HTSDA process, WebSphere Application Server (WAS) is used to streamline the activities along with WebSphere MQ workflow management, and Web-services SOAP calls through WAS to invoke different applications. User can also get the raw HTS data from the local repository. HTSDA Manager manages all components of this applications and is deployed as Web application in WAS. WebSphere InterChange Server (WICS) is used to define the HTS generic data model in a generic Business Object and to choreograph the business processes in Collaborations. HTSDA application specific Business Objects (ASBOs) are specified in certain business integration adapters. WebSphere Portal (WPS) is used as a front-end user interface to provide a Web-based single point of access to the dynamic information, applications, data, and processes. In addition, IBM DB2 Information Integrator (DB2 II) is there to enable federates data access to disparate data sources to do data mining. Applications from different vendors will be integrated directly through the WebSphere BI Adapter Framework and Adapters or wrapped as Web services. After logging in to the Portal, the Portal page will present the scientist the portlets of the accessible applications and data sources according to the scientist's role. The final Hit List is also displayed through portal service.

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Raw HTS Data

Local File Repository

Raw HTS Data

SOAP/HTTP

WebSphere Applic...