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Technical Publication No. 05-007 Novel Catheter for Focused Delivery of an Agent

IP.com Disclosure Number: IPCOM000127735D
Publication Date: 2005-Sep-12
Document File: 2 page(s) / 126K

Publishing Venue

The IP.com Prior Art Database

Related People

Gregory L. Bradley: ATTORNEY

Abstract

The invention is a catheter that is designed to focused the application of a lytic agent near a vessel occlusion and then remove the lytic agent from the blood stream. The catheter consists of three serial elements: 1) hole to release injected lytic agent, (2) balloon that can be inflated to temporarily stop blood flow immediately distal to the thrombus and (3) some arrangement of mechanical projections within the vessel that are designed to maximize surface area. The key feature of the mechanical projections is that they are coated with a lytic binding agent.

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Technical Publication No. 05-007

Novel Catheter for Focused Delivery of an Agent



Arun Ranchod

The invention is a catheter that is designed to focused the application of a lytic agent near a vessel occlusion and then remove the lytic agent from the blood stream. The catheter consists of three serial elements: 1) hole to release injected lytic agent, (2) balloon that can be inflated to temporarily stop blood flow immediately distal to the thrombus and (3) some arrangement of mechanical projections within the vessel that are designed to maximize surface area. The key feature of the mechanical projections is that they are coated with a lytic binding agent.

SPECIFICATION

The catheter hole obviously provides a release point for the injected lytic agent.  This agent will then come into contact with the thrombus (or other occlusion) and act to dissolve the occlusion.  The balloon temporarily occludes vessel blood flow immediately distal to the vascular occlusion that is being lysed.  This will allow the lytic agent to pool in the immediate vicinity of the occlusion, thus increasing both concentration of the lytic agent and duration of time that the lytic agent is in contact with the clot.  After some period of time, the balloon can be deflated to restore blood flow.

The mechanical projections (see attached drawing) immediately distal to the balloon serve several functions. First and foremost, the mechanical projections (think of them as "pine trees" being radially distributed around the catheter) are coated with a lytic binding agent. T hus, when the balloon is deflated and blood flow is restored to the vessel, that volume of blood containing the lytic agent will wash over the treated projections.  As this occurs, some portion of the lytic agent will be passively removed from the blood stream, thus reducing the total amount of lytic agent that will flow through the distal portions of the cerebral vasculature.  This should reduce the probability of the patient suffering from intra-cranial hemorrhage, one of the primary and deadliest side affects of stroke treatment using tPa.  Secondly, the exact configuration of the mechanical projections could act to either trap sections of partially lysed thro...