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A CELLULAR MODEL OF ELECTRICAL CONDUCTION IN THE MAMMALIAN ATRIOVENTRICULAR NODE

IP.com Disclosure Number: IPCOM000128758D
Original Publication Date: 1965-Dec-31
Included in the Prior Art Database: 2005-Sep-19

Publishing Venue

Software Patent Institute

Related People

Larry Karl Flanigan: AUTHOR [+3]

Abstract

This dissertation is concerned with one region of the heart known as the A-V node (the atrioventricular node). A cellular model of the electrical activity in this region is described and the results of a computer simulation of this model are presented. The remainder of Chapter I presents pertinent introductory and background information. Chapters II and III describe excitable cell physiology, especially as pertains to cardiac tissues, and AVCS (atrioventricular conducting system) physiology. Chapter IV presents the cellular model and the computer simulation, and Chapter V contains the results of the simulation. Chapters VI and VII present a comparison of the simulation results with experimental results and a discussion of the results.

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THIS DOCUMENT IS AN APPROXIMATE REPRESENTATION OF THE ORIGINAL.

©; Copyright 1965 by the University of Michigan; used with permission

A CELLULAR MODEL OF ELECTRICAL CONDUCTION IN THE MAMMALIAN ATRIOVENTRICULAR NODE

By Larry Karl Flanigan

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The University of Michigan 196 Doctoral Committee:

Associate Professor Henry H. Swain, Chairman Associate Professor Bernard A. Galler Associate Professor John H. Holland Associate Professor Ernest W. Reynolds, Jr.

ACKNOWLEDGMENTS

The author wishes to express his gratitude to the supervisor of this dissertation, Associate Professor Henry H. Swain, without whom there would be no dissertation. Professor Swain first suggested the topic to the author and then undertook a personal tutoring of the author to provide the necessary knowledge of cardiac anatomy and physiology. Further, throughout the author's labors on this dissertation, Professor Swain made available the resources of his laboratory and the members of his research staff to provide any experimental results required for the dissertation. Finally, the stimulation and encouragement provided by Professor Swain during the difficult periods of the dissertation, especially during its composition, kept the author at the task.

The author is indebted to the other members of his doctoral committee: Associate Professor Bernard A. Galler made a number of suggestions to improve the readability of the dissertation; Associate Professor John H. Holland provided several insights into the model, its mechanisms, and its simulation; Associate, Professor Ernest W. Reynolds, Jr., questioned, corrected, and clarified the author's understanding and presentation of the electrophysiology of cardiac cells and tissues., The author also wishes to acknowledge his debt to Mr. Guy Curtis who performed the experiments which provided the recordings of Chapter III, the author serving only as an assistant in these experiments. Miss Ruth Taipala lettered all of the illustrations in the dissertation and drew all of the plots, relieving the author of these burdens and providing him with valuable additional time for writing in a critical period of dissertation dead-lines.

Finally, the author wishes to express his appreciation to Doctor Gordon K. Moe, of the Masonic Medical Research Laboratory in Utica, New York, for allowing the details of his A-V node model to be communicated to the author, and to Doctor Werner C. Rheinboldt, Director of the Computer Science Center of the University of Maryland, and Mr. Chan Mo Park, also of the Computer Science Center, for two days of interesting and revealing discussion of Dr., Moe's model.

TABLE OF CONTENTS

ACKNOWLEDGMENTS . . . . . . . . . . . . . . . .

LIST OF TABLES . . . . . . . . ... . . .. . . . I . . . . vi

Dec 31, 1965

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A CELLULAR MODEL OF ELECTRICAL CONDUCTION IN THE MAMMALIAN ATRIOVENTRICULAR NODE

LIST OF IL...