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FLORFENICOL

IP.com Disclosure Number: IPCOM000173346D
Publication Date: 2008-Aug-01

Publishing Venue

The IP.com Prior Art Database

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FLORFENICOL

Florfenicol, a structural analogue of thiamphenicol, is a synthetic broad spectrum, primarily bacteriostatic, antibiotic against gram-negative and gram- positive bacteria isolated from domestic animals. It is approved for use in cattle to treat the bovine respiratory disease complex, in swine for the treatment and control of swine respiratory disease.

In this publication, preparation of florenicol premix for medicated feed is described.

Florfenicol, propylene glycol and a part of calcium carbonate were mixed together in a mixer.

After mixing, the mixture was sieved and added to the remaining part of calcium carbonate and homogenized in a suitable mixer.

Composition

Quantity

(g)

Florfenicol

4.00

Propylene glycol

1.00

Calcium Carbonate

Up to 100.00

To obtain the suitable flow properties of premix the anhydrous colloidal silica, talc and other glidants could be added. Various grades/particle size of calcium carbonate can be used.

Crystal

forms of florfenicol which can be used in the above composition are shown below.

XRPD pattern of florfenicol form I

No.

Pos. [°2Th.]

Rel. Int. [%]

d-spacing [A]

1

11,6

100,0

7,65

2

14,2

12,3

6,25

3

16,3

15,1

5,43

4

16,6

37,0

5,34

5

17,4

64,2

5,10

6

19,2

13,1

4,62

7

20,1

15,9

4,43

DSC thermogram of florfenicol form I

FT-IR spectrum of florfenicol form I

XRPD pattern of florfenicol form II + form III

No.

Pos. [°2Th.]

Rel. Int. [%]

d-spacing [A]

1

13,7

32,5

6,45

2

14,1

14,7

6,27

3

16,4

100,0

5,40

4

18,3

25,4

4,84

5

22,0

70,5

4,05

6

24,2

31,3

3,68

7

27,4

68,3

3,25

DSC thermogram of florfenicol form II + form III

FT-IR spectrum of florfenicol form II + form III

XRPD pattern of florfenicol form IV

No.

Pos. [°2Th.]

Rel. Int. [%]

d-spacing [A]

1

14,0

23,1

6,31

2

17,0

39,3

5,21

3

18,0

54,8

4,92

4

18,7

30,1

4,76

5

18,9

91,8

4,70

6

19,1

100,0

4,64

7

20,8

34,3

4,27

DSC thermogram of florfenicol form IV

XRPD pattern of florfenicol form II

No.

Pos. [°2Th.]

Rel. Int. [%]

d-spacing [A]

1

8,1

14,2

10,91

2

16,2

100,0

5,46

3

19,8

5,2

4,49

4

20,2

9,7

4,41

5

21,1

7,6

4,22

6

23,6

6,7

3,78

7

24,4

20,3

3,64

DSC thermogram of florfenicol form II

FT-IR spectrum of florfenicol form II

 

Phosphate buffer, pH= 6,8

Acetate buffer, pH= 4,5

0,1 M

HCl

t (min)

 

 

 

0

0

0

0

5

71

84

94

10

71

91

95

15

72

92

96

20

73

93

97

30

74

96

98

40

79

100

99

Florfenicol premix particles.

Particle size distributions of different batches of florfenic...