Browse Prior Art Database

Process for the preparation of 2-((1-benzylpiperidin-4-yl)methyl-5,6-dimethoxy- 2,3-dihydroinden-1-one hydrochloride

IP.com Disclosure Number: IPCOM000199946D
Publication Date: 2010-Sep-21
Document File: 1 page(s) / 26K

Publishing Venue

The IP.com Prior Art Database

This text was extracted from a PDF file.
At least one non-text object (such as an image or picture) has been suppressed.
This is the abbreviated version, containing approximately 100% of the total text.

Page 1 of 1

Process for the preparation of 2-((1-benzylpiperidin-4-yl)methyl-5,6-dimethoxy- 2,3-dihydroinden-1-one hydrochloride

    Described herein below a process for the preparation of 2-((1-benzylpiperidin- 4-yl)methyl-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride (referred to as "DNP HCl") of the following formula:

O

O

O

. HCl

N

in which the intermediate 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden- 1-one or salt thereof is prepared from 5,6-dimethoxy-2-(pyridine-4-carbonyl)indan-1- one or salt thereof in a one pot manner.

[This page contains 1 picture or other non-text object]