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Screening Test to Identify Patients at Risk for Osteoporosis Who Would Benefit from Imaging

IP.com Disclosure Number: IPCOM000200567D
Original Publication Date: 2010-Oct-19
Included in the Prior Art Database: 2010-Oct-26
Document File: 1 page(s) / 66K

Publishing Venue

Siemens

Related People

Juergen Carstens: CONTACT

Abstract

Bone loss and increased bone fragility (osteoporosis) is a serious condition affecting older individuals. One in three women over the age of 50 years will experience an osteoporotic fracture, and the majority of sufferers are neither identified nor treated. Women taking breast cancer drugs such as aromatase inhibitors are especially prone to bone loss, and are often encouraged to take drugs to reverse the loss. Diagnosis can be achieved through imaging procedures aimed at measuring bone mineral density (BMD). One such procedure is a dual energy X-ray absorptiometry (DEXA) scan. Another is quantitative computerized tomography (QCT). The testing is reasonably accurate but too costly for general screening

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Screening Test to Identify Patients at Risk for Osteoporosis Who Would Benefit from Imaging

Idea: Dr. Michael James Pringle, US-Norwood, MA; Dr. Michael Maschke, DE-Forchheim

Bone loss and increased bone fragility (osteoporosis) is a serious condition affecting older individuals. One in three women over the age of 50 years will experience an osteoporotic fracture, and the majority of sufferers are neither identified nor treated. Women taking breast cancer drugs such as aromatase inhibitors are especially prone to bone loss, and are often encouraged to take drugs to reverse the loss. Diagnosis can be achieved through imaging procedures aimed at measuring bone mineral density (BMD). One such procedure is a dual energy X-ray absorptiometry (DEXA) scan. Another is quantitative computerized tomography (QCT). The testing is reasonably accurate but too costly for general screening

Formerly, osteoporosis was only diagnosed post facto, i.e. after a fracture. The imaging methods described above are able to identify bone loss, but are both costly and do not explain the underlying mechanisms for the loss.

The proposed solution seeks to identify a panel of in vitro tests, which will be combined with patient history parameters using an algorithm to provide an osteoporosis risk score, which may be used as a filter to identify patients who are at risk or who would...