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Copolymers of N-Methacryloyl-L-lysine

IP.com Disclosure Number: IPCOM000201337D
Publication Date: 2010-Nov-11

Publishing Venue

The IP.com Prior Art Database

Abstract

This disclosure relates to copolymers of N-Methacryloyl-L-lysine, their manufacture and applications, such copolymers comprising as polymerized units a) N2-Methacryloyl-L-lysine and/or b) N6-Methacryloyl-L-lysine and c) methacrylic acid and d) optionally further monomers d).

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Copolymers of N-Methacryloyl-L-lysine

   This invention relates to copolymers of N-Methacryloyl-L-lysine, their manufacture and applications.
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    GB 631738 describes the preparation of amphoteric amides of acids of the acrylic acid series, said amides having attached to the amido N-atom an aliphatic radical containing at least one free primary or secondary amino group and one free carboxyl group. In particular, N-methacryloyl lysine and polymers thereof are described.
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US 2002180927 is related to a hydrogel contact lens of high oxygen permeability, the basic material of which is a polymer material containing monomers, which are modified with amino acids, and zwitterionic monomers, which are modified with betaine. Pref- erably, the amino acid, polymerized into the basic material of the contact lens, is pre- sent as methacryloyl amino acid. Preferably, the amino acid monomer and the betaine

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monomer are co polymerized with a main chain and/or a side chain of the matrix mate- rial.

US 5,274,167 describes an optically active N-(meth)acryloyl amino acid amide of the formula (I). The amide is polymerized and optionally bound to a support such as silica,

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    and can then be used for the chromatographic separation of racemic mixtures of phar- macologically active compounds. Preferred optically active N-(meth)acryloyl amino acid derivatives of the formula (I) are the N-methacryloyl derivatives of the tert.-butyl esters of the respective amino acids.
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WO 08/055482 describes a contact lens material which comprises a hydrophilic co- monomer and a hydrophobic comonomer and is characterized in that a free methacry- loyl amino acid is polymerized into the contact lens material.

GB 1466150 describes a process for removing and recovering a metal ions from water

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containing them which comprises incorporating a polymeric material soluble in or swel- lable with water and capable of being bonded with the metal ions into an aqueous solu- tion containing the metal ions thereby forming a chemical or physical bond there be- tween. Said polymeric material may be a homopolymer of a monomer selected from o- acryloylthreonine and N-acryloyllysine or a copolymer predominantly comprised of units

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derived from said monomer, or a salt of said homopolymer or copolymer.

SU 1508548 discloses a method involving the radical copolymerization of acrylamide, a bifunctional monomer-cross-linking agent and a (meth)acryloyl derivative of L-lysine in an aqueous solution in the presence of poly-N-vinylpyrrolidone.

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SU 1462756 discloses a polymeric adsorbent obtained by the radical copolymerization of a hydrophilic monomer, a bifunctional monomer-cross-linking agent and an unsatu-


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rated L-lysine derivative in an aqueous solution using 0.01-0.05 percent poly-L-lysine acylated with (meth)acrylic acid chloroanhydride.

SU 1287541 discloses a method involving the radical copolymerization of a hydrophilic monomer and a bifunctional monomer-cross-linking agent...