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Closed Loop SCS and Chemical Detection

IP.com Disclosure Number: IPCOM000210353D
Publication Date: 2011-Aug-30
Document File: 1 page(s) / 26K

Publishing Venue

The IP.com Prior Art Database

Abstract

The present idea relates to a closed loop spinal cord stimulation (SCS) system consisting of an implanted pulse generator and an electrode array used to treat pain symptoms. A concept of this idea relates to a device used to measure the presence of cyclooxygenase enzymes (COX) which are mediators for the production of prostanoids that cause inflammation and pain.

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Closed

Loop

SCS and Chemical Detection

BACKGROUND

The present idea relates to a closed loop spinal cord stimulation (SCS) system consisting of an implanted pulse generator and an electrode array used to treat pain symptoms. A concept of this idea relates to a device used to measure the presence of cyclooxygenase enzymes (COX) which are mediators for the production of prostanoids that cause inflammation and pain.

Closed loop systems provide bio-feedback by recording or sensing responses following spinal cord stimulation and adapt electrical stimulation therapy based on a sensed response.

DESCRIPTION

This idea relates to stimulation of neural tissue for treating pain by sensing a specific chemical afferent known to cause inflammation or pain including COX-1, COX-2, IL-6 or IL-8.  

Detection of these markers within the blood stream or cerebral spinal fluid (CSF) can assist in determining when electrical therapy should be applied. The biochemical markers can be a signal for impeding or ongoing central sensitization of pain.

Another signal to be used could be the measured heart rate. Spinal cord stimulation decreases oxygen consumption which in general decreases sympathetic tone. Efferent messengers can trigger the sympathetic nervous system which can than alter heart rate.

An implanted blood flow sensor for example could be utilized to determine heart rate. An alternative would be to measure electromyogram (EMG) activity.

The stimulation amplitude and therapy impedance can be a...