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CRYSTALLINE FORM OF DIFFERENT SALTS OF 3, 5-DIMETHYLADAMANTAN-1-AMINE.

IP.com Disclosure Number: IPCOM000211102D
Publication Date: 2011-Sep-20

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The IP.com Prior Art Database

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CRYSTALLINE FORM OF DIFFERENT SALTS OF 3, 5-

DIMETHYLADAMANTAN-1-AMINE.

3,5-Dimethyladamantan-1-amine hydrochloride (also named as 3,5- Dimethyltricyclo[3,3,1,1(3,7)]decan-1-amine hydrochloride), referred to as hydrochloride salt of 'Compound I', has the following formula:

H2N

H

Described hereinafter, are solid state physical properties of other salts of Compound I.

HCl

CH3

CH3



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Crystalline form S1of hydrogen sulphate salt of Compound I:

    Form S1 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 6.2, 13.7, 17.0, 18.7, and 21.2 degrees 2-theta ± 0.2 degrees 2-theta; an X-ray powder diffraction pattern substantially as depicted in Figure 1; and combinations thereof.

Figure 1: an X-ray powder diffraction pattern of crystalline form S1 of Hydrogen sulphate salt of Compound I (peak at 28.48 degrees 2-theta corresponds to Silica powder).

200000

150000

100000

50000

0

    Form S1 can be further characterized by additional X-ray powder diffraction peaks at 13.2, 15.7, 17.2, and 23.6 degrees 2-theta ± 0.2 degrees 2-theta.

Crystalline form S2 of hydrogen sulphate salt of Compound I:

    Form S2 can be characterized by an X-ray powder diffraction pattern having peaks at 5.8, 6.2, 12.4, 17.8, 18.3, and 18.7 degrees 2-theta ± 0.2 degrees 2-theta. The above described Form S2 can comprise a hydrated form of hydrogen sulphate salt of Compound I in a mixture with form S1. This mixture can be characterized by an X- ray powder diffraction pattern substantially as depicted in Figure 2.

    Figure 2: an X-ray powder diffraction pattern of crystalline form S2 of Hydrogen sulphate salt of Compound I (peak at 28.48 degrees 2-theta corresponds to Silica powder).

Intensity(counts)

5 10 15 20 25 30 35

2Theta (°)


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ntensity(counts)

I400000

300000

200000

100000

0

5 10 15 20 25 30 35

    Form S2 can be further characterized by additional X-ray powder diffraction peaks at 13.6, 15.7, 20.0, and 27.6 degrees 2-theta ± 0.2 degrees 2-theta.

Crystalline form S3 of hydrogen sulphate salt of Compound I:

    Form S3 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 6.1, 11.0, 12.2, 14.2, 14.4 and 18.3 ± 0.2 degrees 2- theta; an X-ray powder diffraction pattern substantially as depicted in Figure 3; and combinations thereof.

Figure 3: an X-ray powder diffraction pattern of crystalline form S3 of Hydrogen sulphate salt of Compound I (peak at 28.49 degrees 2-theta corresponds to Silica powder).

2Theta (°)


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Intensity(counts)

120000

100000

80000

60000

40000

20000

0

5 10 15 20 25 30 35

2Theta

(

Form S3 can be further characterized by additional X-ray powder diffraction peaks at
14.8, 17.4, 17.5 and 19.1 ± 0.2 degrees 2-theta.

The above described Form S3 can be a hydrate.

Crystalline form S4 of hydrogen sulphate salt of Compound I:

    Form S4 can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 13.4, 15.4, 17.6, 18.4 and...