Browse Prior Art Database

Compounds for preventing, reducing and/or alleviating itchy skin condition(s)

IP.com Disclosure Number: IPCOM000221594D
Publication Date: 2012-Sep-13
Document File: 110 page(s) / 1M

Publishing Venue

The IP.com Prior Art Database

Abstract

The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.

This text was extracted from a Microsoft Word document.
At least one non-text object (such as an image or picture) has been suppressed.
This is the abbreviated version, containing approximately 2% of the total text.

Munich,                  23 August 2012                                                  

Our Ref.:                 SA 8528-01WO    SOE/ber

Applicant:               SYMRISE AG

Serial Number:         New Application

Symrise AG

Mühlenfeldstraße 1, 37603 Holzminden

Germany

Compounds for preventing, reducing and/or alleviating itchy skin condition(s)

The present invention primarily relates to the use of one or more compounds of the general formula 1 and/or one or more respective salt(s) thereof

(formula 1)

with R1 to R4 and X having the meaning as defined herein below, in particular as defined in the claims, for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist.

Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of compound(s) of formula 1 and/or respective salt(s) thereof and one or more cosmetically and/or pharmaceutically acceptable carriers.

The present invention also relates to cosmetic, preferably non-therapeutic, or therapeutic methods

a)       for preventing, reducing or alleviating one or more itchy conditions, and/or

b)       for providing a PAR-2 antagonistic effect,

wherein compound(s) of formula 1 and/or respective salt(s) thereof or a composition according to the present invention is/are used.

Further aspects of the present invention become apparent by studying the following specification, the examples described herein as well as, in particular, the attached claims.

In particular in the cosmetics and pharmaceuticals industry, there is a constant need for agents having a skin soothing, in particular an itch-reducing or -alleviating action. The skin, in particular the epidermis, as a barrier organ of the human organism is subjected to external influences to a particular extent. Many intrinsic factors (e.g. genetic predisposition) and extrinsic factors (e.g. damage to the skin barrier, dry, especially itchy winter skin, itch-inducing substances) can lead to skin itch, for example skin itch of the scalp.

In connection with this invention, itchy skin is preferably to be understood as meaning any change to the skin which induces sensorial malaise in humans and/or is characterized by the symptoms as dry, reddened or scaly skin. Skin itch can include, be caused or, respectively, be accompanied by phenomenologically different skin states, such as delicate skin, sensitive skin, including sensitive scalp, easily injured skin, atopic skin, irritated skin or inflamed skin, which may manifest itself in an in each case higher severity in itch. In addition, itch is furt...