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Epididymal injection of calcium chloride dihydrate solution (preferably in alcohol) for nonsurgical sterilization in males

IP.com Disclosure Number: IPCOM000223843D
Publication Date: 2012-Nov-30
Document File: 1 page(s) / 159K

Publishing Venue

The IP.com Prior Art Database

Related People

Elaine Lissner: AUTHOR

Related Documents

http://www.docstoc.com/docs/84562692/Single-Testicular-Injection-of-Chlorhexidine-Solution-as-Chemical: URL [+4]

Abstract

Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals. However, when injected into testicular tissue as in those studies, a testosterone reduction results, which would not be appropriate in human males. We propose epididymal rather than testicular tissue injection of calcium chloride dihydrate solution, to avoid affecting testosterone production, as a nonsurgical, non-libido-reducing sterilant in humans. It may also be of use to owners/guardians/managers of companion, zoo, or farm animals who wish to sterilize their animals without changing hormone-linked behavior or health, in addition to providing men with a simple, nonsurgical alternative to vasectomy.

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Calcium chloride dihydrate in alcohol, lidocaine, or saline solution has been extensively studied for nonsurgical neuter for male animals (see Koger LM et al. 1976, 1977, and 1978; Samanta PK and Jana K et al, 1998 to 2011; and Leoci R, forthcoming 2013). However, when injected into testicular tissue as in those studies, a testosterone reduction results that would not be appropriate in human males. We propose epididymal rather than testicular tissue injection of calcium chloride dihydrate solution, to avoid affecting testosterone production, as a nonsurgical, non-libido-reducing sterilant in humans. It may also be of use to owners/guardians/managers of companion, zoo, or farm animals who wish to sterilize their animals without changing hormone-linked behavior or health.

Epididymal injection of calcium chloride dihydrate in saline or alcohol was studied in animals, together with testicular tissue injection, in pilot studies in the 1970’s (see Koger LM, Bovine Practitioner 1977, and Bowman TA et al., Journal of Animal Science Vol. 46 No. 4, 1978). Other chemicals have also been used in animals to sterilize by intra-epididymal injection – for example, Chlorhexidine, in “Efficacy of intratesticular vs intraepididymal injection of Chlorhexidine solution as chemical sterilant in dogs”, R Leoci, G Aiudi, F Silvestre, A Forte, G Lacalandra, Department of Animal Production - University of Bari Aldo Moro, Faculty of Veterinary Medicine, Valenzano (Ba), Italy, presented as poster #155 at The 15th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Antalya, Turkey, 15–17 September 2011.

Though vasectomy is fairly prevalent in industrialized countries, surgical facility challenges limit its use in lower-income countries, and fear of surgery limits its use to generally a maximum of 10-20% of men eve...