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A Crystalline Form of (2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide)

IP.com Disclosure Number: IPCOM000229314D
Publication Date: 2013-Jul-22
Document File: 2 page(s) / 59K

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A Crystalline Form of (2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4- (methylsulfonyl)-benzamide)

When crystallizing (2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)- benzamide) according to example 37, procedure D, as described in US 7,888,364, the following crystalline form is formed:

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Main XRD peaks are: 7.7, 10.3, 14.1, 15.4, 15.8, 18.1, 20.0, 20.7, 21.7 and 23.3 ±


0.2°2theta

XRPD method

Sample after being powdered in a mortar and pestle are applied directly on a silicon plate holder. The X-ray powder diffraction pattern was measured with Philips X'Pert PRO X-ray powder diffractometer, equipped with Cu irradiation source =1.54184 Ǻ (Ǻngström), X'Celerator (2.022º 2θ) detector. Scanning parameters: angle range: 3-40 deg., step size 0.0167, time per step 37 s, continuous scan. The described peak positions were determined using silicon powder as an internal standard in an admixture with the sample measured. The position of the silicon (Si) peak was corrected to silicone theoretical peak: 28.45 degrees two theta, and the positions of the measured peaks were corrected respectively.

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