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Effect of the composition commercialized under the trade-name of AQUAXYL™ on the expression of barrier function-related genes and moisturisation-related proteins

IP.com Disclosure Number: IPCOM000233792D
Publication Date: 2013-Dec-20
Document File: 4 page(s) / 187K

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Effect of the composition commercialized under the trade-name of AQUAXYL™ on the expression of barrier function-related genes and moisturisation-related proteins

AQUAXYL™ is a chemical composition comprising Xylitylpolyglucoside (CAS = 101469-75-4), anhydroxylitol (CAS = 53448-53-6) and xyllitol (CAS = 87-99-0).

            The use of the composition commercialized under the trade-name of AQUAXYL™ as a moisturizing agent for the skin is well-known and the use of Xylitylpolyglucoside for the moisturisation of the skin has been described in the French patent        application published under the publication number FR 2 839 447 A1.

            The composition commercialized under the trade-name of AQUAXYL™ and the Xylitylpolyglucosides comprised is such composition, are prepared by the means of a glycosylation reaction between xyllitol and glucose, involving an acidic catalysis, and more particularly the use of an acid catalysis system which may comprise at least one component selected among the group comprising sulfuric acid, chlorhydric acid, phosphoric acid, nitric acid, hypophosphorous acid, methanesulfonic acid, para-toluene sulfonic acid, trifluorosulfonic acid, acidic ions exchange resins.  

Proper skin barrier function and moisturisation result from appropriate histological structuring and cell-cell communications at both the epidermal and the dermal levels and between these two tissues. More precisely, the establishment and the maintain of the different inter-keratinocyte junctions as well as that of the cornified layer are of a great importance for the skin to ensure its protection function. Among the different kinds of junctions, the presence of aquaporins, and particularly that of one of their main components, aquaporins-3 (AQP-3), has been recently reported as essential.

The composition commercialized under the trade name of AQUAXYL™, comprising Xylityl polyglucosides (XG), is a moisurizing active ingredient, which efficacy had been clinically proven. Its mode of action has been partially elucidated, and some previous results have shown that AQUAXYL™ was able to increase both the production of glycosaminoglycanes (which are considered as “water reservoirs” in the dermis) in normal human fibroblasts and the production  of ceramides in the epidermis.

OBJECTIVE

The aim of the here above study was to further investigate the regulation properties of AQUAXYL™, within the epidermis or within the epidermis main cell components, i.e. keratinocytes, on the genes or proteins involved in skin barrier and moisturisation functions.

METHODOLOGY

A blind transcriptomic screening was performed on reconstructed epidermis (REp) which were composed of normal human keratinocytes (NHK) and which were topically treated with composition comprising for 100% of its weight  3% by mass of AQUAXYL™ (vs. placebo-treated REp). This study was carried out by quantitative (q) reverse transcription (RT)-polymerase c...