Browse Prior Art Database

Chromotography Column With Radial Geometry

IP.com Disclosure Number: IPCOM000234029D
Publication Date: 2014-Jan-08

Publishing Venue

The IP.com Prior Art Database

This text was extracted from a Microsoft Word document.
At least one non-text object (such as an image or picture) has been suppressed.
This is the abbreviated version, containing approximately 17% of the total text.

CHROMOTOGRAPHY COLUMN WITH RADIAL GEOMETRY

[0001]   This publication relates to chromatography separation science. In oilfield industry, this publication is applicable to downhole/surface formation fluid analysis and directed to a method of detection and identification of classes of interest in a formation fluid by a chromatography based device.

[0002]   Analytical chromatography was introduced to the family of laboratory techniques more than a century ago. See M. Tswett, Physical-chemical studies on chlorophyll. The adsorptions. Ber. Deutsch. Botan. Ges., Vol. 24, P. 36, 1906. It involves a propagation of a dissolved in a “mobile phase” mixture through separation components (solid particles or liquid stationary phase). One of the main targets of analytical chromatography is the measurement of the relative proportions of the components of interest in a mixture. To achieve this task the components in the mixture have to be resolved (separated from each other).

[0003]   Traditional chromatography utilizes the tubular or rectangular column of constant geometry: wall coated open tubular, packed, or porous-layer open tubular columns. Recently the theory of chromatographic columns with non-constant geometry was developed. It was shown that in some cases it would be beneficial to alter the column and stationary phase profile to improve the resolution between the components of interest. The profiles that were identified as the most favorable to improve the performance of the chromatographic system have steep geometrical variations along the length of the column and there are many manufacturing challenges to implement them in practice.

[0004]   The proposed instrumentation disclosed in this document describes a new approach for chromatographic composition analysis. This disclosure modifies a principle of traditional chromatography by introducing to the field a new chromatographic column geometry – radial geometry. Chromatographic system that utilizes the columns with proposed geometry provides better resolution between the components of interest and decrease the time required for analysis of complex mixtures.

[0005]   The proposed radial geometry of the chromatographic column is simple to manufacture and coat. It combines a very non-linear pressure profile with variation of stationary phase interacting with solute that, as will be shown, improves the performance of the chromatographic system.

[0006]   Chromatographic columns that are currently implemented in the field of analytical chromatography have a limited ability to resolve the presence of different components in a complex mixture. Utilizing the radial column geometry, it is possible to distinguish between the components that were not separated in cases of traditional geometry. It is also should be mentioned that manufacturing the radial MEMS column and its coating is simple and should allow its rapid introduction into the field. The chromatographic system based on the column with radial geometry incl...