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Crystalline form of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4- pyrimidinyl]-N'-propylsulfamide

IP.com Disclosure Number: IPCOM000235526D
Publication Date: 2014-Mar-06
Document File: 2 page(s) / 103K

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The IP.com Prior Art Database

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Crystalline form of N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4- pyrimidinyl]-N'-propylsulfamide 

     N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'- propylsulfamide referred to as Compound I, has the following chemical structure:

    

Provided is a crystalline form of Compound I. Samples of Compound I were prepared by the process described in example 1, and were analyzed by X-ray powder diffraction ("XRPD") to provide a crystalline form. Figure 1 presents the XRPD of the obtained form.

Figure 1: XRPD of crystalline Compound I 

    According to figure 1, the crystalline form of Compound I is characterized by XRPD peaks at: : 6.6, 8.0, 11.4, 13.1, 14.0, 14.4, 16.1, 17.2, 18.2, 18.5, 18.6, 19.7, 20.1, 21.3, 22.1, 22.7,

Intensity (counts)

25000

20000

15000

10000

5000

0

5 10 15 20 25 30 35 2Theta (°)


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23.0, 23.5, 24.7, 25.4, 25.6, 26.6, 27.7, 28.3, 28.5, 29.8, 31.2, 32.5, 33.0, 33.7, 37.4, 37.6, 38.5 and


39.8 °2theta ± 0.2 °2theta.

XRPD method:

    After being powdered in a mortar and pestle, the samples were applied directly on a silicon plate holder. The X-ray powder diffraction pattern was measured with Philips X'Pert PRO X-ray powder diffractometer, equipped with Cu irradiation source of 1.54184 Ǻ (Ǻngström) and X'Celerator (2.022º 2θ) detector. Scanning parameters: range: 3-40 degrees two-theta; step size: 0.0167 degrees; time per step: 37 sec.; scan mode: continuous scan.

Example 1: Process for preparing the cry...