Browse Prior Art Database

Administration of Collagen Peptides in Combination with further Ingredients for Treatment of Cellulite

IP.com Disclosure Number: IPCOM000236434D
Publication Date: 2014-Apr-25
Document File: 5 page(s) / 60K

Publishing Venue

The IP.com Prior Art Database

Related People

Vivian Zague: AUTHOR

Related Documents

WO 2013/079373 A1: PATAPP

Abstract

Changes in skin relief owing to altered and disturbed extracellular matrix are accepted to be part of cellulite physiopathology and must be a target of cellulite treatments. That is why oral intake of Collagen Peptides is a good strategy to treat cellulite, restoring the normal structure of dermis and subcutaneous tissue, improving cellulite condition and appearance. Nevertheless, cellulite involves multifactorial etiologies and it is characterized by the presence of excess subcutaneous fat that bulges into the dermis, blood and lymphatic disturbances besides altered dermal extracellular matrix. Several approaches are useful for the treatment of cellulite. As with many skin conditions, as a result combinations of different ingredients to influence the different aspects of the pathophysiology of the condition is recommended. Therefore, the positive effects of Collagen Peptides on cellulite can be boosted by associating them with other orally and/or topically applied ingredients, and even physical therapies, acting in different aspects of cellulite pathophysiology. For that reason, we address the effects of Collagen Peptides on strengthening dermal and subcutaneous matrix combined with ingredients able to reduce adipogenesis, increase thermogenesis, improve microcirculation flow and prevent free radical formation or scavenge free radicals in order to encompass the primary routes for cellulite improvement. It is quite possible, also, that synergies between both oral and topical routes may be good strategy to ameliorate the signs and symptoms of cellulite.

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 31% of the total text.

Page 01 of 5

Administration of Collagen Peptides in Combination with further Ingredients for Treatment of Cellulite

Abstract

Changes in skin relief owing to altered and disturbed extracellular matrix are accepted to be part of cellulite physiopathology and must be a target of cellulite treatments. That is why oral intake of Collagen Peptides is a good strategy to treat cellulite, restoring the normal structure of dermis and subcutaneous tissue, improving cellulite condition and appearance.

Nevertheless, cellulite involves multifactorial etiologies and it is characterized by the presence of excess subcutaneous fat that bulges into the dermis, blood and lymphatic disturbances besides altered dermal extracellular matrix. Several approaches are useful for the treatment of cellulite. As with many skin conditions, as a result combinations of different ingredients to influence the different aspects of the pathophysiology of the condition is recommended. Therefore, the positive effects of Collagen Peptides on cellulite can be boosted by associating them with other orally and/or topically applied ingredients, and even physical therapies, acting in different aspects of cellulite pathophysiology.

For that reason, we address the effects of Collagen Peptides on strengthening dermal and subcutaneous matrix combined with ingredients able to reduce adipogenesis, increase thermogenesis, improve microcirculation flow and prevent free radical formation or scavenge free radicals in order to encompass the primary routes for cellulite improvement. It is quite possible, also, that synergies between both oral and topical routes may be good strategy to ameliorate the signs and symptoms of cellulite.

Collagen Peptides & Fat Burners & Ingredients that reduce lipogenesis The most efficient route to adipocyte fat removal would be to increase the levels of mitochondrial uncoupling proteins and 'burn' the fat locally (thermogenesis). Several agents are reported to enhance this process and can be associated with Collagen Peptides, having boosted positive effect on cellulite symptoms.

- Methylxanthines (caffeine, aminophylline, theophylline, theobromine) are used because of their proposed effect on adipocyte lipolysis via inhibition of phosphodiesterase, and increasing cyclic adenosine monophosphate (AMP) levels.


Page 02 of 5

- 2 -

- PPAR agonists, such as conjugated linoleic acid (CLA) and n-3 polyunsaturated fatty acids (PUFA) have been shown to prevent lipid accumulation in adipocytes, decrease subcutaneous fat thickness which was related to reduced size of adipocytes, and reduce adipose invagination into the dermis, improving the appearance of cellulite.

- Centella asiatica has been shown significant reduction in the diameter of adipocytes especially in the gluteo-femoral region and a decrease in interadipocyte fibrosis.

- Hydroxycitrate from Garcinia cambogia, also known as Malabar tamarind, is a lipogenesis inhibitor and it has been used on its own or together with Gym...