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TECHNIQUE FOR TARGETED DELIVERY OF ACTIVE PRINCIPLES ACROSS THE BLOOD-BRAIN BARRIER

IP.com Disclosure Number: IPCOM000237275D
Publication Date: 2014-Jun-11
Document File: 5 page(s) / 88K

Publishing Venue

The IP.com Prior Art Database

Abstract

The invention proposes technique for targeted delivery of an active principal across a blood-brain barrier by a beam in a MRI system. The invention includes two techniques to deliver the active principles in a human body and disrupt the blood brain barrier to allow the active principle to permeate into a brain tissue. First technique includes magnetic resonance navigation where an MRI scanner or potentially equipped with additional hardware, such as, enhanced gradient coils generate magnetic force. Magnetic force is generated with computer feedback to control position of magnetic particles carrying the active principle. The magnetic force is applied by energizing an electromagnet, which enables to superimpose a magnetic field gradient over the main magnetic field of the MRI scanner. The magnetic field gradient has a linear or nonlinear geometry depending on what is appropriate. The MRI scanner controls the position of the magnetic particles and directs towards an area in a patient body where the active particles are released. Another technique includes release mechanism of the active principle.

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TECHNIQUE FOR TARGETED DELIVERY OF ACTIVE PRINCIPLES ACROSS THE BLOOD-BRAIN BARRIER

 

BRIEF ABSTRACT

The invention proposes technique for targeted delivery of an active principal across a blood-brain barrier by a beam in a MRI system. The invention includes two techniques to deliver the active principles in a human body and disrupt the blood brain barrier to allow the active principle to permeate into a brain tissue. First technique includes magnetic resonance navigation where an MRI scanner or potentially equipped with additional hardware, such as, enhanced gradient coils generate magnetic force. Magnetic force is generated with computer feedback to control position of magnetic particles carrying the active principle. The magnetic force is applied by energizing an electromagnet, which enables to superimpose a magnetic field gradient over the main magnetic field of the MRI scanner. The magnetic field gradient has a linear or nonlinear geometry depending on what is appropriate. The MRI scanner controls the position of the magnetic particles and directs towards an area in a patient body where the active particles are released. Another technique includes release mechanism of the active principle.

KEYWORDS

Target delivery, active particle, blood-brain carrier, MR scanner


DETAILED DESCRIPTION

Generally, conventional techniques allow target and transport of therapeutic magnetic particles across a brain barrier in a magnetic resonance imaging (MRI) system.

For example, a conventional technique includes a linear gradient coil to induce the magnetic force. However, the conventional technique requires frequent switching coils and large biodegradable particle, which targets region slowly.

Therefore, there is a need for a technique that provides efficient targeted delivery of an active principle across a blood brain barrier.

The invention proposes techniques for targeted delivery of an active principle across a blood-brain barrier by a beam in a magnetic resonance imaging (MRI) system. The invention includes two techniques to deliver the active principles in a human body and disrupt the blood brain barrier to allow the active principle to permeate into a brain tissue. First technique includes magnetic resonance navigation where an MRI scanner or potentially equipped with additional hardware such as enhanced gradient coils generate magnetic force. The magnetic force is generated with computer feedback to control position of magnetic particles carrying the active principle. The magnetic force is applied by energizing an electromagnet, which enables to superimpose a magnetic field gradient over the main magnetic field of the MRI scanner. The magnetic field gradient has a linear or nonlinear geometry depending on what is appropriate. The MRI scanner controls the position of the magnetic particles and directs towards an area in a patient body where the active particles are released. Second technique includes release mechanism of the active principle. The techni...