Tunable piezo-driven sieve consisting of a multi-nanopore chip
Publication Date: 2014-Aug-07
The IP.com Prior Art Database
Disclosed is a design for a tunable multi-nanopore array that can be continuously closed and opened in a reversible manner. The idea is to employ piezoelectric materials, which allow nanometer precision in opening and closing the pore.
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Tunable piezo -
Fabrication of solid-state nanopores results in a fixed pore diameter allowing only the translocation of molecules of a certain size. As the current change is largely a function of the volume of a molecule, smaller molecules cannot be detected due to a small current change and larger molecules are not able to translocate at all . Only one company is presently known to produce a single tunable nanopore chip made from an elastic material. [1, 2]
The novel contribution is a design for a tunable multi -nanopore array that can be continuously closed and opened in a reversible manner . The idea is to employ piezoelectric materials, which allow nanometer precision in opening and closing the pore.
In the first approach, two multi-nanopore chips are placed on top of each other . (Figure
Figure 1: First approach to a piezoelectric turntable with multi-nanopore chip
The lower chip is mounted on a piezoelectric arm and the upper chip on a fixed arm .
Applying voltage to the piezoelectric arm the lower chip can be moved with nanometer precision, therefore decreasing the nanopore channel width . A third multi-nanopore
-driven sieve consisting of a multi
driven sieve consisting of a multi - -nanopore chip
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chip can be placed on top of the other two , which can be moved by a piezoelectric arm perpendicular to the other, allowing a circular rather than a half moon shape of the tunable nanopores.
In a second approach, the piezoelectric material is placed in the nanopore. (Figure 2) Hence, an applied voltage across the entire chip leads to an expansion of the piezoelectric material, leading to a decrease of the nanopore diameter .
Figure 2: Second approach to a piezoelectric turntable with multi-nanopore chip
In a third approach, the nanopores are laid out in a single row and two piezoelectric arms are used to move two chips with nanometer precision, one from each side of the nanopores, leading to a more rectangular tuned nanopore shape . (Figure 3) Note that the top-down view of the chip in Figure 3is not accurate as drawn, in order to show the arrangement of the components relative to each other . In act...