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METHOD AND SYSTEM FOR QUANTIFICATION OF ZINC USING DUAL-ENERGY COMPUTED TOMOGRAPHY

IP.com Disclosure Number: IPCOM000238815D
Publication Date: 2014-Sep-19
Document File: 3 page(s) / 28K

Publishing Venue

The IP.com Prior Art Database

Abstract

The invention proposes a non-invasive technique for estimation of amount of zinc in pancreas through dual-energy computed tomography (CT) imaging. The invention further allows for determination and visual representation of estimated amount of zinc by overlapping a zinc map onto an underlying image.

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METHOD AND SYSTEM FOR QUANTIFICATION OF ZINC USING DUAL-ENERGY COMPUTED TOMOGRAPHY

BRIEF ABSTRACT

The invention proposes a non-invasive technique for estimation of amount of zinc in pancreas through dual-energy computed tomography (CT) imaging. The invention further allows for determination and visual representation of estimated amount of zinc by overlapping a zinc map onto an underlying image.

KEYWORDS

Zinc quantify, dual energy computed tomography, pancreas, algorithm


DETAILED DESCRIPTION

Zinc is generally required to either assemble insulin molecules or precipitate insulin crystals in pancreatic beta cells. Lack of zinc concentration in the beta cells results in a decreased insulin production. Usually, blood test is performed to measure insulin in a living body. However, methods that measure insulin in the blood cannot provide spatial distribution of zinc in pancreas.

A noninvasive method that measures islet cell loss and also tracks fate of transplanted islets facilitates development of therapeutics and improves management of diabetes.

For example, in a conventional technique 18F-fallypride binding to isolated rat islets and pancreas is evaluated in the absence and presence of the D2/D3R inhibitor haloperidol. After intravenous 18F-fallypride administration, normal rats and rats pretreated with haloperidol were imaged in a PET/CT scanner. Subsequently ex vivo for 18F-fallypride localization in the pancreas is studied. Further, isolated islets were stained with zinc based dithizone to quantify the yield and to estimate purity. However, the above mentioned conventional technique does not provide an estimate of amount of zinc in pancreas.

Alternative techniques for in viv...