Browse Prior Art Database

PROCESS FOR PREPARATION OF OLANZAPINE PAMOATE MONOHYDRATE

IP.com Disclosure Number: IPCOM000239173D
Publication Date: 2014-Oct-20
Document File: 2 page(s) / 10K

Publishing Venue

The IP.com Prior Art Database

Abstract

The present disclosure relates to a process for the preparation of olanzapine pamoate monohydrate, wherein olanzapine base is treated with pamoic acid in a solvent, the obtained clear solution is added to a surfactant and/or emulsifier in water to obtain olanzapine pamoate monohydrate with desired particle size.

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 64% of the total text.

Page 01 of 2

The present disclosure is to provide a process for the preparation of olanzapine pamoate monohydrate with desired particle size using a surfactant and/or emulsifier.

O OH

OH O

Olanzapine Pamoate monohydrate

Olanzapine and pamoic acid are dissolved in a solvent to get a clear solution, which is then added to a surfactant and/or emulsifier in water, the obtained solution is stirred and filtered to get olanzapine pamoate monohydrate with desired particle size.

The olanzapine pamoate is dissolved in a solvent selected from N-methylpyrrolidine, dimethylformamide, dimethylacetamide or dimethylsulfoxide.

The surfactant and/or emulsifier used in this experiment is selected from cationic surfactants, anionic surfactants, nonionic surfactants and amphoteric or zwitterionic surfactants.

The cationic surfactant is selected from trimethylalkylammonium chlorides and the chlorides and bromides of benzalkonium and alkylpyridinium ions and the anionic surfactant is selected from alkylbenzene sulfonates, soaps, lauryl sulfate, dialkyl sulfosuccinate, lignosulfonates and the zwitterionic surfactant is selected from cocamidopropyl betaine, lecithinand the nonionic surfactant is selected form ethoxylated linear alcohols, ethoxylated alkyl phenols, fattyacid esters, amine and amide derivatives, alkylpolyglucosides, polyoxyethylene ether of anhydrous sorbitol.

Example-1: Preparation of Olanzapine pamoate monohydrate

Olanzapine (100 g), pamoic acid (124.3 g) and dimethyl sulfoxide (750...