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Glass Microsphere- or Superparamagnetic Iron Oxide Nanoparticle- Containing Bandages for Surface Hemostasis

IP.com Disclosure Number: IPCOM000240571D
Publication Date: 2015-Feb-10
Document File: 1 page(s) / 65K

Publishing Venue

The IP.com Prior Art Database

Related People

Thomas H. Fischer, Ph.D.: INVENTOR

Abstract

Simplified methods are presented for the preparation of non-adhesive bandages that contain pro-hemostatic micro- or nanoparticles. Platelet-activating microparticles (glass microspheres or superparamagnetic iron oxide (SPIO)) are associated with fibers of bamboo or silk, two types of fibers that agglutate red blood cells (RBCs). The resulting pro-hemostatic microparticle textiles are anticipated to be useful for controlling hemorrhage in surgeries, childbirth, or trauma.

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  Glass Microsphere- or Superparamagnetic Iron Oxide Nanoparticle- Containing Bandages for Surface Hemostasis

Abstract-Simplified methods are presented for the preparation of non-adhesive bandages that contain pro-hemostatic micro- or nanoparticles. Platelet-activating microparticles (glass microspheres or superparamagnetic iron oxide (SPIO)) are associated with fibers of bamboo or silk, two types of fibers that agglutate red blood cells (RBCs). The resulting pro-hemostatic microparticle textiles are anticipated to be useful for controlling hemorrhage in surgeries, childbirth, or trauma.

Background-The need for cost-effective bandage dressings that reduce blood loss in human and veterinary medicine is widely appreciated. This need can be satisfied if a material that activates hemostatic reactions, such as glass microspheres or SPIO, is combined with a textile fiber that agglutinates RBCs, such as rayon bamboo or silk. The agglutination of RBCs has been shown to render bandages non-adhesive so that re- bleeding is minimized when bandages are removed. Relevant material-science principles are detailed elsewhere1. The motivation of this disclosure is to make widely available a simplified technique for manufacturing hemostatic textiles.

Details of the Invention- Preparation of glass microsphere or SPIO nanoparticle particle-containing hemostatic textiles proceeds as follows.

1a. Glass microspheres- Glass microspheres (e.g., hollow e-glass) are combined with fibers of bamboo or silk through intrinsic adherence mechanisms by mixing the microsp...