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FLAT PANEL DETECTOR FOR MICROTITER PLATE IMAGING

IP.com Disclosure Number: IPCOM000241068D
Publication Date: 2015-Mar-24
Document File: 5 page(s) / 299K

Publishing Venue

The IP.com Prior Art Database

Abstract

The present invention provides a flat panel detector for microtiter plate imaging. The proposed technique includes a detector panel which is either amorphous silicon or complementary metal–oxide–semiconductor (CMOS) based, and a lid, which is either opaque or reflective that keeps external light from entering into the system. Distance between the detector and the lid is at least 3 cm or more to accommodate standard height of microtiter plates. There is a protective layer on top of the detector panel to keep the detector clean and free from contamination from chemical or biological samples. According to the technique described herein, detector elements are provided only at each circular microtiter plate well.

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FLAT PANEL DETECTOR FOR MICROTITER PLATE IMAGING

BACKGROUND

The present invention relates generally to imaging a microtitre plate and more particularly to a flat panel detector for microtiter plate imaging.  

Conventional techniques for microtitre plate imaging utilize a charge-coupled device (CCD) camera for image detection. Such camera requires a large distance (of about several centimeters) to be maintained between a sample and the camera.  Such large distance restricts amount of light that can be captured, and thereby increases image acquisition time. 

Further, conventional techniques utilize a scanning laser beam to excite each plate and hence such systems are large, non-portable, and take long time to capture images. For example 10 minutes or more per image. The large size does not allow for a reduced form factor for the instrument for freeing up bench space in the lab and field use applications.  Furthermore, the conventional techniques are not cost effective.

It would be desirable to have an effective technique for microtiter plate imaging.

BRIEF DESCRIPTION OF DRAWINGS

Figure 1 depicts a top view and a side view of a microtiter plate.

Figure 2 depicts a microtiter plate detector in a first configuration.

Figure 3 depicts the microtiter plate detector in an alternate configuration.

Figure 4 depicts a top view of the microtiter plate detector having multiplexing based readout electronics.

 


DETAILED DESCRIPTION

The present invention provides a flat panel detector for microtiter plate imaging.  An imager with the flat panel detector allows rapid imaging of microtiter plate samples and improves productivity of chemistry and biology laboratories.  For samples that have transient behavior, where emitted light changes over time, rapid imaging allows for accurate characterization of sample concentrations.

Figure 1 depicts a top view and a side view of a typical microtiter plate having 96 or more defined wells that contain biological or chemical samples.  Each sample may be stained by a fluorescent, chemiluminescent or colorimetric dye which interacts with a biological or chemical agent to produce light.  The amount and wavelength range of the light produced is detected to determine concentration of a target biological or chemical agent.  Utilizing the proposed amorphous silicon flat panel detector technology reduces size of the imaging system.  Further, the proposed technique offers better sensitivity and resolution.

 

Figure 1

Figure 2 depicts a microtiter plate detector in a first configuration.  The proposed technique includes a detector panel which is either amorphous silicon or complementary metal–oxide–semiconductor (CMOS) based, and a lid, which is either opaque or a reflective that keeps external light from entering into the system. For example, distance between the detector and the lid is at least 3 cm or more to accommodate standard height of microtiter plates.  There is a protective layer or protective sheet ...