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Customizable Modular Assembly for High Throughput Chromatography and Methods for Ease of Use

IP.com Disclosure Number: IPCOM000241172D
Publication Date: 2015-Apr-01
Document File: 7 page(s) / 151K

Publishing Venue

The IP.com Prior Art Database

Abstract

Rapid knowledge generation technologies are useful to diverse areas of industry, from high throughput organic chemistry and biotechnology to energy services designing custom chemistry solutions. The technical market would benefit from a modular, flexible chromatography system that simultaneously evaluates both miscible and immiscible liquids without contamination. These systems are necessary to investigate innovative material and chemical solutions where surface energies and free energy are important. The design of this system would comprise multiple columns using standard multi-well arrangements and would provide fluid flow control. Personnel may easily perform a variety of tests using this high-throughput system to create new knowledge with a high degree of accuracy.

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Page 01 of 7

Customizable Modular Assembly for High Throughput Chromatography and Methods for Ease of Use

Abstract

Rapid knowledge generation technologies are useful to diverse areas of industry, from high throughput organic chemistry and biotechnology to energy services designing custom chemistry solutions. The technical market would benefit from a modular, flexible chromatography system that simultaneously evaluates both miscible and immiscible liquids without
contamination. These systems are necessary to investigate innovative material and chemical solutions where surface energies and free energy are important. The design of this system would comprise multiple columns using standard multi-well arrangements and would provide fluid flow control. Personnel may easily perform a variety of tests using this high-throughput system to create new knowledge with a high degree of accuracy.

Introduction

A novel cross-platform equipment system design involves a deep-well collection plate, filter plate, frit or screen with funnels to allow for fluid exit (fluid in this paper is described as any substance that obeys fluid mechanic or dynamic principles, or continually deforms or flows under an applied shear stress). However, control of the flow of fluids in similar systems is limited to the use of a sealing mat, which seals off the funnels of the filter plate so such that liquids do not flow out of the column. Control of fluids is desirable in chromatography applications requiring incubation steps or time-dependent measurements, for example, such that the volume of fluid eluted from the column or filter plate and collected in each well of the collection plate can be analyzed in an ultrasonic volume reader, UV-Vis spectrophotometer or other appropriate instrument. Furthermore, the current multi-well systems can only be used for liquid testing, and cannot be used for gas analyses. Additional problems addressed by our invention include incompatible materials for both the column and frit, and sealing/leak issues associated with the commercial plates and sealing mats currently used for flow control.

Description

Multi-well Column

Block

Screen or frit Multi-well Flow Control Device

Collection Plate


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Modular Multi-well Chromatography System. The modular design of the equipment allows for ease of assembly, reduction of time, and labor considerations over the use of individual columns. This new equipment design provides the chemical material compatibility of equipment material and the testing material. The new equipment also allows for reduction of waste in waste disposal protocols due to its reusable nature and can be designed with consideration for autoclave sterilization if desired. With this new equipment, the operational variables and mistakes are diminished providing better quality control. The redesign also allows for custom (e.g., modular and adaptable) adaptations of the equipment to suit testing such as gas chromatography testing. Additionally...