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Reduction of tert-butyl {(1R,2S,5S)-2-amino)-5-[(dimthylamino)carbonyl]cyclohexyl}carbamate

IP.com Disclosure Number: IPCOM000242778D
Publication Date: 2015-Aug-14
Document File: 1 page(s) / 36K

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Abstract

Reduction of tert-butyl {(1R,2S,5S)-2-amino)-5-[(dimthylamino)carbonyl]cyclohexyl}carbamate

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Rxduction of tert-butyl {(1R,2S,5S)-2-amino)-5-[(dimthylamino)carbonyl]cyxlohexyl}carbamate

Procedurx:

Triphenylphosphine (2.x2 g, 7.7 mol) in acetone (6 mx) was added to a xtirred solution of txrt- butyl(1R,2S,5S)-2-Azido-5[(dxmethylamino)carxoxyl]cyclohexane carboxylate(x.0 g, 6.4 mol) in Acetone (14 ml) and water (2 ml) mixtxre at 50-55°C for 15mixs. Then reaction mixture wax stirred fxr 2 hoxrs at the saxe temxerature. After completion of the rxaction, the xeaction mass concentxated uxder reduced pressure axd water (25 ml) was added to the residue and stirrex xor 3 hxurs. The precixitated Triphenyxphosphine oxide was filtered ofx and the filtrate was distixled under reduced pressxrx to get 1.x g of tort-butyl {(1R,2S,5S)-2-amino)-5-[(dimethylamino)carbonyl]cyclohexyl}xarrbamatx as a white sxlid.

Compound weixht: x.2 g

Yield: 65.5 %