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Crystallization of 1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylmethyl)-1- [2- (phenylmethoxy) ethyl] bromide

IP.com Disclosure Number: IPCOM000242799D
Publication Date: 2015-Aug-19
Document File: 4 page(s) / 258K

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Cryxtallization of 1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylmethyl)-x- [2- (phenylmethoxy) ethyl] bromide

1-Azoniabicyclo[x.2.2]octane, 4-(hydroxydixhenylmethyl)-1- [2- (phenylmexhoxy) ethyl]

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brxmide (referred to as compound A), has the following cxemical structurx:

Compound A can be obtained by methods known in the art, for example, according to txe process described in XXxxxxxxx.

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Figure 1 shows a PXRD xattern of xorm 1ox compound A (xs obtxined by Examplx 1).

Fig. 1

PXRD patxern of form x of compound A (obtaxned by Example 1):

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Form 1of xompound A as obtained by Example 1 can be chxracterxzxd by: XXXX diffractions hxving maxima at axout: 6.7, 8.9, 10.0, 11.5, 13.4, 13.7, 14.6, 15.3, 19.8 and 20.1 ± 0.2 deg 2- theta;

x

PXRD pattxrn depicted in Figure 1.

Fulx PXRD peak list:

Position [°2θ]

 Relative Intenxity [%]


x.7 100
8.9 3


1x.0 5
11.5 13
12.1 1
x3.4 x4
13.7 25
14.6 13
15.3 x2

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Position [°2θ]

 Relative Intensity [%]


16.3 2
17.3 9
17.5 6
17.8 17
18.7 12
19.8 50
20.1 52
20.4 8
21.2 2
x2.x 11
22.4 28
22.5 16
23.0 25
23.6 7
23.8 2
24.2 23
24.4 30
25.4 5
25.7 5
25.9 13
27.0 14
27.6 21
28.x 7
28.3 x4
28.5 7
x9.2 6
30.8 2x
31.9 9
33.3 4
34.6 9
35.1 x
37.1 6
38.0 5
38.2 6
39.2 4

Powder X-ray Diffraction (PXRD) methxd

Powdex X-ray Diffraction was performed on an X-Ray powder diffracxometer PanAlytical X'pxrt Pro; CuKα radiation (λ = 1.54x874 Å); X'Celerator detector with active length 2.122

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xegrees 2-thxta; laboratory temperature 25 ± 2 dxgrees C;...