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7 4 4 2 3 dichlorophenyl piperazin 1 yl butoxy 2 oxo 3 4 dihydroquinolin 1 2H yl methoxy methyl dodecanoate

IP.com Disclosure Number: IPCOM000243685D
Publication Date: 2015-Oct-11
Document File: 1 page(s) / 327K

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((7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)- yl)methoxy)methyl dodecanoate

((7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)- yl)methoxy)methyl dodecanoate, referred to as Compound I, has the following structure:

Compound I may be an impurity of (7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2- oxo-3,4-dihydroquinolin-1(2H)-yl)methyl dodecanoate, for example at levels of about 0% to about 0.1%, or 0.1% to about 0.5%. or approximately 0.5%.

Described herein below, is a process for preparing compound I:

Procedure:

Compound 1 can be prepared as follows:

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one is combined with excess of chloromethyl dodecanoate in organic solvent selected from the group consisting of: ethers, amides, esters, nitriles, sulfoxide, ketones, hydrocarbons, acetate, halogenated hydrocarbon and inert solvent. Preferably the solvent is inert solvent. the reaction is done at a temperature of 20oC-100oC with the presence of a base selected from a group consisting of: organic base, inorganic base, aqueous solution of organic base; preferably the base is inorganic base. Compound I was purified by silica gel chromatography.