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Photostabilization of the combination Ethylhexyl Methoxycinnamate and Tris Biphenyl Triazine

IP.com Disclosure Number: IPCOM000244779D
Publication Date: 2016-Jan-14
Document File: 5 page(s) / 88K

Publishing Venue

The IP.com Prior Art Database

Abstract

Disclosed is the use of specific ingredients which are able to photostabilize the combination of the two UV filters Ethlyhexyl Methoxycinnamate (EHMC) and Tris Biphenyl Triazine (TBPT, Tinosorb A2B).

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Photostabilization of the combination Ethylhexyl Methoxycinnamate and Tris Biphenyl Triazine

Disclosed is the use of specific ingredients which are able to photostabilize the combination of the two UV filters Ethlyhexyl Methoxycinnamate (EHMC) and Tris Biphenyl Triazine (TBPT, Tinosorb A2B from BASF SE).

Background

It is well known that ultraviolet radiation (light) is harmful to human skin. Depending on the wavelength, UV radiation causes different types of skin damage. UV-B radiation is mainly responsible for sunburn; another major adverse effect is DNA damage that can, on the long run, lead to skin cancer. UV-A radiation while producing tanning of the skin, contributing also to sunburn is mostly responsible for chronic photo-damages and for the induction of skin cancers. Therefore, an effective sunscreen formulation should show an uniform absorbance over the complete UV range to ensure optimal protection.

Very often, UV filters such as Ethylhexyl Methoxycinnamate absorb rather in the UVB range . Other UV filters such as Diethylamino Hydroxybenzoyl Hexyl Benzoate absorb in the UVA range. Few broad-spectrum UV filters such as Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine or Methylene Bis-Benzotriazolyl Tetramethylbutylphenol absorb over the complete UV-A and UV-B range. Trade products contain a mixture of UV absorbers to achieve the desired SPF and fulfill UVA requirements such as the ISO24443. Yet, very often there is a gap in the UVAII (320- 340nm) range for optimal UV protection. The organic particulate UV filter Tris Biphenyl Triazine fills this gap as the molecule absorbs in the UVB and UVAII range.

Therefore, the combination of TBPT with a UVB filter such as EHMC and an additional UVA filter is ideal for achieving homeostatic photoprotection. However, it was found that the combination of EHMC and TBPT results in a photoinstability of EHMC under UV irradiation.

Photostabilization of the combination Ethylhexyl Methoxycinnamate and Tris Biphenyl Triazine


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Photostabilization of the combination Ethylhexyl Methoxycinnamate and Tris Biphenyl Triazine

Discussion

Surprisingly it has been found that following ingredients show photostabilizing effects on the above-mentioned UV filter combination EHMC + TBPT:

 Uvinul N539T, INCI: Octocrylene (OCR) from BASF SE

 Tinosorb S, Bis-Ethylhexyl Methoxycinnamate (BEMT) from BASF SE

 Synoxyl HSS, INCI: Trimethoxybenzylidene Pentanedione from Syntheo

 Tinogard TT, INCI: Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate from BASF SE

 Tinogard LO1, INCI: Acetoxytetramethylbutylphenyl Tetramethylbutylbenzofuranone from

BASF SE

 Lycopene Redivivo from Sigma Aldrich

 Tempol from from Sigma Aldrich

 Lucarotin 30M form BASF SE

Test Protocol for the Determination of the photostability of UV Filters in cosmetic formulation by High Performance Liquid Chromatography

An amount of 5.6 mg of tested sunscreen formulation is equally applied to quartz plates with ro...