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Preparation of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide)

IP.com Disclosure Number: IPCOM000245115D
Publication Date: 2016-Feb-09
Document File: 1 page(s) / 280K

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Preparation of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-

4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide)

A reactor was charge with 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7- tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (28 g) and N-Methyl-2- pyrrolidone (10 volumes) (at room temperature). The reaction mixture was cooled to 0oC and 5-chloropentanoyl chloride was added dropwise. The reaction was stirred and then, sodium ethoxide solution (85 mL) was added. The reaction was stirred until reaction completion. After acidic quench, and water addition, the desired product was filtrated and dried.