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PROCESS FOR THE PREPARATION OF ODANACATIB

IP.com Disclosure Number: IPCOM000246672D
Publication Date: 2016-Jun-27
Document File: 4 page(s) / 709K

Publishing Venue

The IP.com Prior Art Database

Related People

Mahesh Gadakar: AUTHOR

Related Documents

Odanacatib.IP.COM: IP.COM

Abstract

The present disclosure relates to a novel process for the preparation of odanacatib

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PROCESS FOR THE PREPARATION OF ODANACATIB

Odanacatib (MK-0822) is a cathepsin K inhibitor being developed for the treatment of osteoporosis and bone metastasis.

Odanacatib is chemically named (2S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino] pentanamide and is represented by the following chemical structure:

The present disclosure relates to a novel process for the preparation of odanacatib, which represents in following schemes.

Scheme-I:

Scheme-II:

Scheme-III: