AUTOMATED VOXEL POSITION OPTIMIZATION FOR IN VIVO MAGNETIC RESONANCE SPECTROSCOPY
Publication Date: 2016-Dec-12
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Automated Voxel Position Optimization for In Vivo Magnetic Resonance Spectroscopy
MRS voxel placement in the hippocampus using anatomical images. The orange and yellow boxes indicate the
planned voxel location corresponding to the resonances of NAA and water, while the green box indicates the
The optmisation relates to MR spectroscopy, in which MR spectra data are acquired from localised
volumes, e.g. voxels based on gradient selection. That is , a limited bandwidth RF excitation is
employed together with spatially selective magnetic gradient fields. The gradient direction are adjusted so as to reduce sensitivity of voxel location close to tissue
boundaries. In this way the MR spectral acquisition is made less sensitive to chemical shifts of
volumes from which MR spectra of different chemical compounds are acquired. Further the local
shim volume to reduces B0 inhomgeneities is shifted away from tissue boundaries.
This reduces the error in MR spectrometry owing to chemical shifts and magnetic field shimming.
Poor water suppression and magnetic field shimming, as well as increased outer volume signal
bleed, are three of the most common sources of reduced MRS data quality that limit the clinical
utility of MRS. This invention reduces the dependence on local user expertise in MRS voxel planning
by enabling automated calculation of the optimal chemical shift displacement directions and shim
volume placement, leading to improved MRS data quality and reliability, and f...