Browse Prior Art Database

Non-Destructive Measurement of Moisture in Blisters

IP.com Disclosure Number: IPCOM000249373D
Publication Date: 2017-Feb-22
Document File: 2 page(s) / 327K

Publishing Venue

The IP.com Prior Art Database

Abstract

Disclosed is a method to provide quick and robust moisture measurements of packaging blisters in a non-destructive way. The novel solution is to incorporate an internal RH circuit into the blister pack and provide a means to easily read the RH via a hand held device.

This text was extracted from a PDF file.
This is the abbreviated version, containing approximately 52% of the total text.

1

Non-Destructive Measurement of Moisture in Blisters

Pharmaceutical tablets and powders are often packed in aluminum blister packs. Maintaining the appropriate level of moisture in packaging blisters is an important variable for product viability. It is critical to maintain moisture levels below a certain limit to avoid microbial growth. The presence of moisture also affects the products ability to flow. Measuring the moisture levels in aluminum blister packs is therefore a critical practice.

The current method for measuring moisture is manual and the number of blisters that can be tested is quite limited. A technology is needed that can provide quick and robust moisture measurements in a non-destructive way.

Key Success Criteria: · Work with blisters 10mm long, 4mm wide and 2mm high · Can detect moisture in sealed laminated aluminum foil blisters · Ability to detect relative humidity in the blisters ranging from 5-75% · Non-destructive testing · Speed and accuracy · Potential to work in Good Manufacturing Practice (GMP) environment

Figure: Schematic of blister packaging with aluminum foils at the top and bottom. The distance from the edge of strip to the start of blister is about 3.5 mm.

The novel solution is to incorporate an internal RH circuit into the blister pack and provide a means to easily read the RH via a hand held device.

The approach is to build the circuitry on the back of the polyvinyl chloride (PVC) layer. The RH sensor is incorporated into the blister itself and is attached via conductive adhesive to lines patterned in the Al foil. These lines...