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Gatuline® Link n Lift, an active ingredient extracted from Aesculus hippocastanum flowers, and associated cosmetic formulations

IP.com Disclosure Number: IPCOM000249674D
Publication Date: 2017-Mar-16
Document File: 30 page(s) / 4M

Publishing Venue

The IP.com Prior Art Database

Abstract

This document contains cosmetic formulations destined to treat wrinkles and smooth the skin, containing an extract of Aesculus Hippocastanum.

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 WHAT IT DOES

The eyes truly reflect our emotions, however the eye contour area is known to age faster than other areas. Indeed, the fragility of the skin around the eyes and its permanent motion favor the formation of wrinkles. These wrinkles, under-eye and tear trough wrinkles in particular, can lead to undesired negative expressions such as sadness, fatigue and sternness.

Gatuline® Link n Lift restores the features of the skin for a younger and fresher look. Used at 2% in formulation, Gatuline® Link n Lift visibly acts on all eye contour wrinkles: crow’s feet, under-eye and tear trough (also called valley of tears). The double blind clinical study versus placebo confirms this eye contour rejuvenation, with the first effects visible in just 2 weeks. The wrinkles are visibly reduced, the skin is toned and smoother.

Volunteer #2 – under-eye wrinkles (fringe projection – 3D visuals)

 

Volunteer #14 – tear trough (fringe projection – 3D visuals)

                       

HOW IT WORKS

Demonstrated in vitro on skin cells, Gatuline® Link n Lift directly acts on both the dermal-epidermal junction and the dermis.

Gatuline® Link n Lift acts in depth, in the dermis, on fibroblast dynamism and mobility to help the skin fight matrix degradation.

80% increase of the migratory capacity of fibroblasts vs untreated

Gatuline® Link n Lift reinforces the dermal-epidermal junction integrity and functionality by stimulating the synthesis of all major components involved in the epidermis-dermis cohesion and communication:

·         Type IV collagen

·         Type VII collagen

·         Fibronection

·         Laminin-5

·         Laminin-10

·         Integrin α6β4

Quantitative measurement of fibronectin by immunolabeling

WHAT IT IS

The first active derived from horse chestnut flower and obtained using NaDES technology (Natural Deep Eutectic Solvents), Gatuline® Link n Lift is rich in active molecules found only in the flower.

NaDES technology allows the creation of active compositions unattainable with conventional solvents. Natural, non-toxic and efficient at low temperatures, this technology is perfectly aligned with Gattefossé’s strategy to provide high-performance sustainable ingredients.

The horse chestnut flowers are selectively and manually picked in the Ardèche (France), ensuring a truly responsible sourcing and organic certification for the ingredient.

In the heart of the Regional Natural Park of the Mounts of Ardèche stand century-old horse chestnut trees

The following formulations have been developed to demonstrate the properties of Gatuline® Link n Lift, hereafter written “ Aesculus Hippocastanum extract”.

SOOTHING DAY CREAM FOR SENSITIVE SKINS  

   

Phase Material Name INCI Supplier Properties % Material

A DEMINERALIZED WATER WATER - - QS100

CARBOPOL ULTREZ 21 ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER LUBRIZOL gelling agent 0,10

GLYCERIN GLYCERIN - moisturizing agent 3,00

BUTYLENE GLYCOL BUTYLENE GLYCOL - dispersing agent, solubilizer 5,00

PENTYL...