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IMPACT OF SILICONE POLYMERS ON BOTH LIDOCAINE DELIVERY AND FORMULATION PROPERTIES

IP.com Disclosure Number: IPCOM000251108D
Publication Date: 2017-Oct-12
Document File: 34 page(s) / 2M

Publishing Venue

The IP.com Prior Art Database

Related People

Laurie Maes: INVENTOR [+4]

Abstract

Dow offers multiple polymer technologies that can be used to enhance the properties of topical formulations. This document reports three case studies recently performed to demonstrate the influence of various silicone polymers on both lidocaine delivery and long-lasting properties of three main formulation types: a water-in-oil emulsion (case study 1), an anhydrous gel (case study 2), and an aqueous gel (case study 3). Those studies revealed that silicone polymer technologies can improve and offer a sustained delivery of lidocaine by enhancing the long-lasting properties of the formulation on the skin surface. In addition it was shown that the versatility of both silicone and cellulose chemistry provides to the formulator a wide range of technologies with various functionalities and characteristics that can potentially increase product efficacy and improve patient compliance.

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Impact of silicone polymers on both lidocaine delivery and formulation properties Authors: L. Maes, X. Thomas, M. Eeman, V. Caprasse Abstract Dow offers multiple polymer technologies that can be used to enhance the properties of topical formulations. This document reports three case studies recently performed to demonstrate the influence of various silicone polymers on both lidocaine delivery and long-lasting properties of three main formulation types: a water-in-oil emulsion (case study 1), an anhydrous gel (case study 2), and an aqueous gel (case study 3). Those studies revealed that silicone polymer technologies can improve and offer a sustained delivery of lidocaine by enhancing the long-lasting properties of the formulation on the skin surface. In addition it was shown that the versatility of both silicone and cellulose chemistry provides to the formulator a wide range of technologies with various functionalities and characteristics that can potentially increase product efficacy and improve patient compliance.

*********************************************** Dow offers multiple polymer technologies that can be used to enhance the properties of topical formulations. This document reports three case studies recently performed to demonstrate the influence of various silicone polymers on both lidocaine delivery and long-lasting properties of three main formulation types: a water-in-oil emulsion (case study 1), an anhydrous gel (case study 2), and an aqueous gel (case study 3). 1. Silicone polymers under investigation Three silicone polymer families were considered for the three case studies.

Silicone Fluid Silicone Elastomer Silicone Gum Blend Structure (schematic drawing)

Commercial name Dow Corning® Q7- 9120 Silicone Fluid, 20 cSt

Dow Corning® ST-Elastomer 10

Dow Corning® Dimethiconol Blend 20

INCI name Dimethicone Cyclopentasiloxane and Dimethicone Crosspolymer

Dimethicone and Dimethiconol

Description High-purity non- volatile Silicone Fluids tested according to and complies with USP-NF non-parenteral requirements for Dimethicone and with all EP requirements for Dimeticone monograph.

A blend of silicone elastomer in volatile silicone

High molecular weight dimethicone dispersed in non- volatile carrier

Benefits in healthcare applications

- Skin protectancy - Non occlusivity - Emolliency - Substantivity - Lubrication - Spreadability

- Non occlusive - Contributes to

silky aesthetics properties: smooth, dry feel

- Rheology modifier to adjust formulation consistency, thickener for silicone- containing formulations

- film forming agent

- non-volatile diluent

- Gives a more lubricious, long lasting after feel

- Substantive material

- Non occlusive

2. Case Study 1: Evaluation of Water-in-oil Emulsion The aim of this first case study is to show the efficiency of three silicone polymers formulated in a Water-in-Oil (W/O) emulsion to deliver lidocaine combined with various formulation benefits.

2.1.Impact of silicone polymers on both the release and...